Product image of Humulin R U-500 500 [iU]/mL (Insulin human) 500 [iU]/mL INJECTION, SOLUTION supplied by GNH India

Humulin R U-500 500 [iU]/mL

Active Ingredient:
Insulin human
Form:
INJECTION, SOLUTION
Brand:
Humulin R U-500
Origin:
USA

Humulin R U-500 500 [iU]/mL (Insulin human INJECTION, SOLUTION) 500 [iU]/mL

Insulin human, the active ingredient in Humulin R U-500, is a short-acting insulin presented as a 500 [iU]/mL injection solution for subcutaneous use. It is used to manage diabetes mellitus in patients requiring high insulin doses, including those with type 1 or type 2 diabetes. GNH India supplies Humulin R U-500 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Humulin R U-500 is specifically designed for patients who need more than 200 units of insulin per day. It is available in a concentrated form to facilitate easier administration for those with significant insulin requirements.

Strength

500 [iU]/mL

Pack Size

1 VIAL, MULTI-DOSE in 1 CARTON (0002-8501-01) / 20 mL in 1 VIAL, MULTI-DOSE

Manufacturer / TM Owner

Eli Lilly and Company

1
Pack/s
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Indications & Clinical Uses

Humulin R U-500 is a short-acting insulin used to manage diabetes mellitus, particularly in patients with high insulin requirements. It is indicated for the following conditions:

  • Type 1 diabetes mellitus: Helps manage blood glucose levels in patients who require insulin due to insufficient insulin production.
  • Type 2 diabetes mellitus (high insulin requirements): Used in patients who need more than 200 units of insulin per day to control their blood sugar levels.
  • Diabetes management in patients with significant insulin resistance: Assists in achieving glycemic control in individuals who do not respond adequately to lower concentrations of insulin.

How It Works

  • Humulin R U-500 works by activating insulin receptors, which promotes cellular glucose uptake and utilization while inhibiting hepatic glucose production. This mechanism helps to lower blood glucose levels and manage diabetes mellitus effectively.

Side Effects

Humulin R U-500, like other insulin products, can cause various side effects. Common Side Effects:

  • Hypoglycemia: Low blood sugar levels, which can cause symptoms such as sweating, dizziness, and confusion.
  • Injection site reactions: Redness, swelling, or itching at the injection site.
  • Weight gain: Increased body weight due to improved glucose utilization and storage.
  • Peripheral edema: Swelling in the extremities due to fluid retention.

Serious or Rare Side Effects

  • Hypokalemia: Low potassium levels, which can lead to muscle weakness and irregular heartbeat.
  • Lipodystrophy: Changes in fat distribution at the injection site, which can affect insulin absorption.
  • Allergic reactions: Severe allergic responses, including anaphylaxis, which require immediate medical attention.
  • Hypersensitivity reactions: Allergic reactions that can manifest as rash, itching, or difficulty breathing.

Precautions & Warnings

Humulin R U-500 should be used with caution and under medical supervision. Important precautions include:

  • Monitor blood glucose levels regularly: Frequent monitoring is essential to avoid hypoglycemia or hyperglycemia.
  • Adjust dosage as directed: Dosage adjustments should be made by a healthcare professional based on individual needs.
  • Avoid mixing with other insulins: Humulin R U-500 should not be mixed with other insulin products to prevent dosing errors.
  • Inform healthcare providers of all medications: Certain drugs can interact with Humulin R U-500, affecting its efficacy or safety.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Humulin R U-500 can interact with various medications, which may affect its efficacy or increase the risk of side effects. Major Interactions (Avoid):

  • Oral antidiabetic agents: Concurrent use can increase the risk of hypoglycemia.
  • Angiotensin-converting enzyme (ACE) inhibitors: May enhance the hypoglycemic effect of insulin.
  • Monoamine oxidase inhibitors (MAOIs): Can potentiate the hypoglycemic effect of insulin.

Moderate Interactions (Monitor Closely)

  • Beta-blockers: Can mask symptoms of hypoglycemia and interfere with glucose metabolism.
  • Corticosteroids: May reduce the hypoglycemic effect of insulin.
  • Thiazide diuretics: Can decrease insulin sensitivity and increase blood glucose levels.

Frequently Asked Questions

Humulin R U-500 is a short-acting insulin used to manage diabetes mellitus, particularly in patients with high insulin requirements. It is indicated for type 1 diabetes mellitus and type 2 diabetes mellitus in individuals who need more than 200 units of insulin per day. The medication helps to control blood glucose levels and is administered subcutaneously.

Insulin human, the active ingredient in Humulin R U-500, works by activating insulin receptors in the body. This promotes the uptake of glucose by cells, enhances glucose utilization, and inhibits hepatic glucose production. By mimicking the action of natural insulin, it helps to lower blood glucose levels and manage diabetes effectively.

The dosage of Humulin R U-500 is determined by a healthcare professional based on individual patient needs, blood glucose levels, and response to therapy. It is crucial to follow the prescribed dosage and adjust it as directed by the healthcare provider to avoid hypoglycemia or hyperglycemia.

Humulin R U-500 is classified as pregnancy category B, indicating that no proven risk in humans has been established. However, it should be used during pregnancy only if clearly needed and under medical supervision. For breastfeeding, the safety of Humulin R U-500 has not been fully established, and caution is advised. Always consult a healthcare provider before using this medication during pregnancy or breastfeeding.

To order Humulin R U-500 from GNH India, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will then provide pricing, availability, shipping details (including cold-chain logistics where relevant), and the necessary import paperwork.

Humulin R U-500 is a short-acting insulin used for managing diabetes in patients with high insulin requirements, while Ozempic (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist used for type 2 diabetes. Humulin R U-500 requires subcutaneous injection and has a rapid onset of action, whereas Ozempic is administered once weekly and works by increasing insulin secretion and reducing glucose production in the liver.

Humulin R U-500 should be stored at 2-8°C, refrigerated, and protected from light. It should not be frozen or shaken. Always keep the medication in its original packaging until use. Proper storage is essential to maintain the efficacy and safety of the medication.

Humulin R U-500 is administered subcutaneously, typically in the abdomen, thigh, or upper arm. It is essential to rotate injection sites to prevent lipodystrophy. The medication should be injected using a syringe specifically designed for U-500 insulin to ensure accurate dosing. Always follow the healthcare provider's instructions for administration.

The most serious risks associated with Humulin R U-500 include severe hypoglycemia, allergic reactions, and hypersensitivity reactions. Symptoms of severe hypoglycemia include confusion, loss of consciousness, and seizures. Allergic reactions can manifest as rash, itching, or difficulty breathing. Immediate medical attention is required if any of these symptoms occur.

Humulin R U-500 should not be used by individuals who are allergic to insulin human or any of the excipients in the formulation. It should be used with caution in patients with hypoglycemia unawareness, severe renal or hepatic impairment, and in the elderly. Always consult a healthcare provider before starting Humulin R U-500 to ensure it is suitable for your medical condition.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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