Product image of INDOMETHACIN 50 mg/1 (Indomethacin) 50 mg/1 SUPPOSITORY supplied by GNH India

INDOMETHACIN 50 mg/1

Active Ingredient:
Indomethacin
Form:
SUPPOSITORY
Brand:
INDOMETHACIN
Origin:
USA

INDOMETHACIN 50 mg/1 (Indomethacin SUPPOSITORY) 50 mg/1

Indomethacin, the active ingredient in INDOMETHACIN 50 mg/1, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a 50 mg suppository for rectal use. It is used to relieve moderate to severe pain, tenderness, swelling, and stiffness caused by various forms of arthritis and other inflammatory conditions. GNH India supplies INDOMETHACIN 50 mg/1 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

INDOMETHACIN 50 mg/1 is a trusted product for managing inflammatory conditions, ensuring patients receive effective relief from pain and inflammation. GNH India is committed to providing high-quality pharmaceuticals to meet global healthcare needs.

Strength

50 mg/1

Pack Size

30 SUPPOSITORY in 1 BOX (0054-1950-30)

Manufacturer / TM Owner

Hikma Pharmaceuticals USA Inc.

1
Pack/s
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Indications & Clinical Uses

INDOMETHACIN 50 mg/1 is used to manage pain and inflammation associated with various conditions. It is particularly effective in treating:

  • Rheumatoid arthritis: Reduces pain, swelling, and stiffness in the joints.
  • Ankylosing spondylitis: Alleviates inflammation and pain in the spine.
  • Osteoarthritis: Helps manage joint pain and inflammation.
  • Acute gouty arthritis: Provides relief from severe pain and inflammation during gout attacks.
  • Acute painful shoulder (bursitis and/or tendinitis): Reduces pain and inflammation in the shoulder joint.

How It Works

  • Indomethacin works by inhibiting the cyclooxygenase (COX) enzymes, which are responsible for the production of prostaglandins. By reducing prostaglandin synthesis, indomethacin decreases inflammation, pain, and fever. This mechanism makes it effective in managing various inflammatory conditions and providing relief from pain.

Side Effects

INDOMETHACIN 50 mg/1, like other NSAIDs, can cause a range of side effects. Common Side Effects:

  • Headache
  • Dizziness
  • Dyspepsia (indigestion)
  • Nausea
  • Serious or Rare Side Effects:
  • Cardiovascular thrombotic events (e.g., heart attack, stroke)
  • Gastrointestinal bleeding, ulceration, and perforation
  • Hepatotoxicity (liver damage)
  • Hypertension (high blood pressure)
  • Renal toxicity and hyperkalemia (high potassium levels)
  • Anaphylactic reactions (severe allergic reactions)
  • Serious skin reactions (e.g., Stevens-Johnson syndrome)

Precautions & Warnings

INDOMETHACIN 50 mg/1 should be used with caution and under medical supervision. Important precautions include:

  • Avoid use in patients with a history of peptic ulcer disease or gastrointestinal bleeding: Increased risk of bleeding and ulceration.
  • Monitor patients with preexisting asthma: May exacerbate asthma symptoms.
  • Use with caution in patients with renal impairment: May worsen kidney function.
  • Avoid use in patients with a history of proctitis or recent rectal bleeding: May cause further irritation.
  • Store at 2° to 8°C: Keep refrigerated, protect from light, and do not freeze.

Avoid Interactions

INDOMETHACIN 50 mg/1 can interact with other medications, potentially altering their effects or increasing the risk of side effects. Major Interactions (Avoid):

  • Anticoagulants (e.g., warfarin): Increased risk of bleeding.
  • Aspirin: May reduce the anti-inflammatory effects of indomethacin.
  • ACE inhibitors (e.g., lisinopril): May reduce the antihypertensive effects and increase the risk of kidney damage.
  • Moderate Interactions (Monitor Closely):
  • Diuretics (e.g., furosemide): May reduce the diuretic effect and increase the risk of kidney damage.
  • Methotrexate: Increased risk of methotrexate toxicity.
  • Lithium: May increase lithium levels, leading to toxicity.

Frequently Asked Questions

INDOMETHACIN 50 mg/1 is used to relieve moderate to severe pain, tenderness, swelling, and stiffness caused by various forms of arthritis, including rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It is also effective in treating acute gouty arthritis and acute painful shoulder conditions such as bursitis and tendinitis.

Indomethacin works by inhibiting the cyclooxygenase (COX) enzymes, which are responsible for the production of prostaglandins. By reducing prostaglandin synthesis, indomethacin decreases inflammation, pain, and fever. This mechanism makes it effective in managing various inflammatory conditions and providing relief from pain.

The usual dose of INDOMETHACIN 50 mg/1 is determined by a healthcare professional based on the patient's condition and response to treatment. It is important to follow the prescribed dosage and administration instructions provided by the healthcare provider.

INDOMETHACIN 50 mg/1 is classified as a pregnancy category C drug, meaning it should be used during pregnancy only if the potential benefits justify the potential risks. It is not recommended for use during breastfeeding. Always consult a healthcare professional before using this medication during pregnancy or breastfeeding.

To order INDOMETHACIN 50 mg/1 from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will reply with pricing, availability, shipping, and the necessary import paperwork.

INDOMETHACIN 50 mg/1 is a potent NSAID with strong anti-inflammatory and analgesic properties. Compared to other NSAIDs, it may have a higher risk of side effects, particularly gastrointestinal issues. The choice of NSAID depends on the patient's specific condition, medical history, and response to treatment.

INDOMETHACIN 50 mg/1 should be stored at 2° to 8°C, kept refrigerated, and protected from light. It should not be frozen. Always follow the storage instructions provided on the packaging to ensure the medication remains effective and safe to use.

INDOMETHACIN 50 mg/1 is administered rectally as a suppository. It is important to follow the administration instructions provided by the healthcare professional to ensure proper use and effectiveness of the medication.

The most serious risks associated with INDOMETHACIN 50 mg/1 include cardiovascular thrombotic events (e.g., heart attack, stroke), gastrointestinal bleeding, ulceration, and perforation, hepatotoxicity (liver damage), and serious skin reactions. Patients should be monitored closely for these potential risks.

INDOMETHACIN 50 mg/1 should not be used by patients with a history of peptic ulcer disease, gastrointestinal bleeding, or severe renal impairment. It is also contraindicated in patients with a history of proctitis or recent rectal bleeding. Always consult a healthcare professional before using this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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