Product image of Intelence (Etravirine) supplied by GNH India

Intelence

Active Ingredient:
Etravirine
Origin:
EU

Intelence (Etravirine)

Etravirine, the active ingredient in Intelence, is a Non‑nucleoside reverse transcriptase inhibitor (NNRTI) presented as a tablet for oral use. It is indicated for the treatment of HIV‑1 infection in combination with other antiretroviral agents, helping to suppress viral replication in adults and adolescents.

GNH India supplies Intelence as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Janssen-Cilag International Nv

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Indications & Clinical Uses

Intelence (etravirine) is used in the management of HIV‑1 infection, a viral disease treated with antiretroviral therapy.

  • HIV‑1 infection: used in combination with other antiretroviral agents to achieve viral suppression.

How It Works

  • Etravirine binds to the non‑nucleoside reverse transcriptase inhibitor site on HIV‑1 reverse transcriptase, inhibiting both RNA‑dependent and DNA‑dependent DNA polymerase activity. This blockade prevents the conversion of viral RNA into DNA, thereby halting viral replication and reducing viral load in the patient.

Side Effects

Adverse reactions may occur with Intelence and should be monitored.

Common Side Effects

  • Rash: mild to moderate skin eruptions.
  • Nausea: occasional upset stomach.
  • Headache: transient head discomfort.
  • Diarrhea: loose stools.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention.
  • Hepatic failure: signs of liver dysfunction.
  • Severe hypersensitivity: including anaphylaxis.
  • Pancreatitis: inflammation of the pancreas.
  • Severe depression or suicidal thoughts.

Precautions & Warnings

Before initiating Intelence, certain precautions are recommended.

  • Assess hepatic function: evaluate liver enzymes prior to therapy.
  • Monitor for rash: watch for skin changes and report promptly.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Review concomitant medications: check for potential drug interactions.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Intelence may interact with several medicines; awareness of interaction severity is essential.

Major Interactions (Avoid)

  • Ritonavir‑boosted protease inhibitors: may increase etravirine levels.
  • Efavirenz: can reduce etravirine efficacy.
  • Nevirapine: may lead to reduced therapeutic effect.

Moderate Interactions (Monitor Closely)

  • St. John’s wort: may decrease plasma concentrations.
  • Antacids containing aluminum or magnesium: can affect absorption.
  • Warfarin: monitor INR for potential anticoagulant effect changes.

Frequently Asked Questions

Intelence contains etravirine and is prescribed as part of combination antiretroviral therapy to treat HIV‑1 infection in adults and adolescents. It works alongside other agents to suppress viral replication and improve immune function.

Etravirine binds to a specific non‑nucleoside site on the HIV‑1 reverse transcriptase enzyme, blocking its ability to synthesize DNA from viral RNA. This inhibition stops the virus from replicating within host cells, reducing viral load.

The dosage of Intelence is determined by the prescribing clinician based on individual patient factors, including other antiretroviral medications, resistance profile, and clinical response. Patients should follow the prescriber’s instructions exactly.

The safety of etravirine in pregnancy and lactation has not been fully established. Healthcare providers should weigh potential benefits against risks and consider alternative regimens when treating pregnant or nursing individuals.

To request Intelence, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Intelence (etravirine) offers a distinct resistance profile and can be effective in patients with certain NNRTI‑resistant HIV strains. Compared with older NNRTIs such as efavirenz, it may have a different side‑effect spectrum and drug‑interaction profile, making it a valuable option in tailored combination regimens.

Intelence tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid exposure to extreme temperatures.

Intelence is taken orally as a tablet, usually with food to improve absorption. Patients should swallow the tablet whole with water and follow the dosing schedule prescribed by their healthcare provider.

Serious risks include severe skin reactions such as Stevens‑Johnson syndrome, hepatic failure, hypersensitivity reactions, pancreatitis, and significant neuropsychiatric events. Prompt medical evaluation is essential if any of these symptoms develop.

Patients with known hypersensitivity to etravirine or any component of the tablet should avoid Intelence. Additionally, individuals with severe hepatic impairment or those taking contraindicated medications should not be prescribed this drug.

Reviewed by

Dr. Shweta Ashok More

M.Pharm (Quality Assurance), Ph.D. (Medicinal Chemistry)

Content approved 11 Aug 2026

Last updated:

References

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