JANUMET XR 500 mg/1 (Sitagliptin and Metformin Hydrochloride TABLET, FILM COATED, EXTENDED RELEASE) 500 mg/1

JANUMET XR 500 mg/1 combines sitagliptin and metformin hydrochloride for extended-release oral administration. This medication is designed to help manage certain health conditions related to blood sugar levels. It is commonly used as part of a treatment plan for improving glycemic control.

Strength

500 mg/1

Pack Size

1000 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (0006-0078-82)

Manufacturer / TM Owner

Merck Sharp & Dohme LLC

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Indications & Clinical Uses

JANUMET XR 500 mg/1 is primarily used to help manage blood sugar levels in adults with type 2 diabetes. This medication works by combining two active ingredients, sitagliptin and metformin hydrochloride, to improve glycemic control. It is often prescribed alongside diet and exercise to achieve better health outcomes. The extended-release formulation is designed to provide a steady release of the medication over time.

Side Effects

Common effects of JANUMET XR 500 mg/1 may include gastrointestinal discomfort, such as nausea or diarrhea, especially when first starting the medication. Some users may also experience headaches or a mild metallic taste in the mouth. These effects are generally temporary and may subside as the body adjusts to the medication. Always consult a healthcare provider for personalized advice.

Precautions & Warnings

JANUMET XR 500 mg/1 should be taken as directed by a healthcare provider. It is important to follow the prescribed dosage and administration instructions. This medication should be stored at room temperature, away from moisture and heat. Patients with certain medical conditions, such as kidney or liver problems, should discuss their health status with a healthcare provider before starting this medication.

Avoid Interactions

JANUMET XR 500 mg/1 may interact with other medications, including certain antibiotics, antifungal agents, and medications that affect kidney function. Alcohol consumption should be avoided while taking this medication, as it can increase the risk of side effects. Always inform your healthcare provider about all medications and supplements you are taking to avoid potential interactions.

Frequently Asked Questions

JANUMET XR 500 mg/1 is used to help manage blood sugar levels in adults with type 2 diabetes. It combines sitagliptin and metformin hydrochloride to improve glycemic control.

JANUMET XR 500 mg/1 should be taken orally, usually once daily with a meal, as directed by a healthcare provider. The extended-release tablets should not be crushed or chewed.

Common side effects may include gastrointestinal discomfort, nausea, diarrhea, headaches, and a mild metallic taste in the mouth. These effects are usually temporary.

JANUMET XR 500 mg/1 may interact with other medications, so it is important to inform your healthcare provider about all medications and supplements you are taking.

Patients with kidney or liver problems should discuss their health status with a healthcare provider before starting JANUMET XR 500 mg/1. Alcohol consumption should be avoided.

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Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical wholesaler & exporter

Last updated: 17 Jun 2026

References

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