JUBLIA 8ml (Efinaconazole Topical Soln) 10% x 8ml

JUBLIA is a triazole antifungal medication used to treat fungal infections of the toenails. It is specifically indicated for onychomycosis caused by Trichophyton rubrum and Trichophyton mentagrophytes.

• Onychomycosis: Treats fungal infections of the toenails caused by specific types of fungi.
• Toenail fungus: Helps to clear and prevent the recurrence of fungal infections in the toenails.
• Tinea unguium: Addresses fungal infections that affect the toenails, promoting healthy nail regrowth.

• Efinaconazole works by inhibiting fungal lanosterol 14α-demethylase, which disrupts ergosterol synthesis. This compromises the integrity of the fungal cell membrane, leading to the death of the fungal cells. By targeting this specific enzyme, efinaconazole effectively stops the growth and spread of the fungus.

JUBLIA may cause side effects at the application site. Common side effects include mild irritation and discomfort, while serious or rare side effects are less frequent but require immediate medical attention.

Common Side Effects

• Ingrown toenail: May occur at the site of application.
• Application-site dermatitis: Redness, itching, or swelling at the application site.
• Application-site vesicles: Small blisters or fluid-filled sacs at the application site.
• Application-site pain: Discomfort or pain at the site of application.
• Redness: Mild redness at the application site.
• Itching: Mild itching at the application site.
• Swelling: Mild swelling at the application site.
• Burning or stinging: Mild burning or stinging sensation at the application site.

Serious or Rare Side Effects

• Severe allergic reaction: Rare but possible, with symptoms such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and trouble breathing.

JUBLIA should be used with caution and according to the prescribed instructions. Important precautions include avoiding contact with certain areas and ensuring proper storage.

• Application site: Use JUBLIA only on nails and surrounding skin. Do not use in the mouth, eyes, or vagina.
• Pregnancy: Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.
• Breastfeeding: Use with caution in nursing women, as the safety is not established.
• Children: Safety and effectiveness in children under 6 years of age have not been established.
• Flammability: JUBLIA is flammable. Avoid heat and flame while applying and until the medication has dried.
• Medical conditions: Inform your doctor about all medical conditions, especially if you are pregnant, breastfeeding, or have other nail infections.
• Store at room temperature: Keep the container tightly closed, store in an upright position, and avoid freezing or exposing to heat or flame [webmd.com](https://www.webmd.com/drugs/jublia-efinaconazole).

JUBLIA may interact with other medications, and it is important to inform your healthcare provider about all medications you are taking. Major interactions should be avoided, while moderate interactions require close monitoring.

Major Interactions (Avoid)

• None identified.

Moderate Interactions (Monitor Closely)

• Other topical medications: Avoid using other topical medications on the same area without consulting your healthcare provider.
• Systemic antifungals: Inform your doctor if you are taking other systemic antifungals to avoid potential interactions.
• Immunosuppressants: Inform your doctor if you are taking immunosuppressants, as they may affect the efficacy of JUBLIA.
• Corticosteroids: Inform your doctor if you are taking corticosteroids, as they may affect the efficacy of JUBLIA.
• Antihistamines: Inform your doctor if you are taking antihistamines, as they may affect the efficacy of JUBLIA.