Product image of Ketonal 100 Mg (Ketoprofen) supplied by GNH India

Ketonal 100 Mg

Active Ingredient:
Ketoprofen
Origin:
EU

Ketonal 100 Mg (Ketoprofen)

Ketoprofen, the active ingredient in Ketonal 100 Mg, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a 100 mg injection for intramuscular or intravenous use. It treats mild to moderate pain and inflammatory conditions in adults.

GNH India supplies Ketonal 100 Mg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lek Pharmaceuticals D.D. Ljubljana

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Indications & Clinical Uses

Ketoprofen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.

  • Mild to moderate pain: provides analgesic relief for acute or chronic pain conditions.
  • Arthritis (e.g., osteoarthritis, rheumatoid arthritis): decreases joint inflammation and improves mobility.
  • Post‑operative pain: helps control pain after surgical procedures.
  • Musculoskeletal injuries: reduces pain and swelling associated with strains, sprains and other injuries.

How It Works

  • Ketoprofen exerts its effect through non‑selective inhibition of cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis lowers inflammation, diminishes peripheral sensitisation of nociceptors, and produces analgesic and antipyretic actions.

Side Effects

Ketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastro‑intestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache or dizziness.
  • Injection‑site reactions: erythema, swelling or pain at the site.
  • Transient elevation of liver enzymes.

Serious or Rare Side Effects

  • Gastro‑intestinal bleeding or ulcer perforation.
  • Acute renal impairment or failure.
  • Severe cutaneous reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Anaphylactic or severe hypersensitivity reactions.
  • Hepatic failure or severe hepatitis.

Precautions & Warnings

When prescribing Ketonal, clinicians should consider several safety factors.

  • Renal function: assess baseline kidney status and monitor during therapy.
  • Cardiovascular risk: avoid in patients with uncontrolled hypertension or heart failure.
  • Gastro‑intestinal history: use cautiously in those with prior ulcer disease or bleeding.
  • Concomitant anticoagulants: monitor for increased bleeding tendency.
  • Pregnancy and lactation: reserve for situations where benefits outweigh potential risks.
  • Store below 25°C: keep in the original container, protect from light and moisture.

Avoid Interactions

Ketonal can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened risk of bleeding.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): increased bleeding potential.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal function when combined.
  • Diuretics: potential for renal impairment.
  • Lithium: ketoprofen may raise serum lithium concentrations.

Frequently Asked Questions

Ketonal 100 Mg contains ketoprofen, an NSAID indicated for the relief of mild to moderate pain, reduction of inflammation in arthritic conditions, control of post‑operative discomfort, and management of musculoskeletal injuries. It is administered by a healthcare professional via intramuscular or intravenous injection.

Ketoprofen works by non‑selectively inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for prostaglandin production. Lower prostaglandin levels lead to reduced inflammation, diminished pain signalling, and a modest antipyretic effect.

The appropriate dose of Ketonal 100 Mg is determined by the prescribing clinician based on the patient’s condition, severity of symptoms, and clinical response. Dosage may vary for different indications and routes of administration.

Ketoprofen’s safety in pregnancy and lactation is not well established. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and only under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Ketonal (ketoprofen) offers a potency comparable to ibuprofen and naproxen but has a slightly longer half‑life, allowing less frequent dosing in some settings. Like other non‑selective NSAIDs, it shares similar gastrointestinal and renal risk profiles, so choice often depends on clinician preference, patient tolerance and specific therapeutic needs.

Ketonal 100 Mg should be stored below 25 °C in its original packaging, protected from light and moisture. Do not freeze the product. Handling should be performed by trained personnel using aseptic technique for intramuscular or intravenous administration.

Ketonal is given by a qualified healthcare professional as an intramuscular or intravenous injection. The route, injection site and rate of administration are selected according to the clinical indication and patient condition.

Serious adverse events include gastrointestinal bleeding or ulcer perforation, acute renal failure, severe skin reactions such as Stevens‑Johnson syndrome, anaphylaxis, and hepatic failure. Patients should be monitored for signs of bleeding, renal dysfunction, rash or respiratory distress, and treatment should be stopped immediately if these occur.

Ketonal should be avoided in individuals with known hypersensitivity to ketoprofen or other NSAIDs, active peptic ulcer disease, severe renal or hepatic impairment, uncontrolled heart failure, and in patients receiving anticoagulant therapy unless closely monitored. It is also contraindicated in the third trimester of pregnancy.

Reviewed by

Dr. Shweta Ashok More

M.Pharm (Quality Assurance), Ph.D. (Medicinal Chemistry)

Content approved 18 Aug 2026

Last updated:

References

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