Product image of Ketonal (Ketoprofen) supplied by GNH India

Ketonal

Active Ingredient:
Ketoprofen
Origin:
EU

Ketonal (Ketoprofen)

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a topical formulation for skin application. It reduces pain and inflammation associated with musculoskeletal disorders and is used in adults who need localized relief.

GNH India supplies Ketonal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz D.O.O.

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Indications & Clinical Uses

Ketonal, a topical NSAID, is applied to conditions involving inflammation and pain in the musculoskeletal system.

  • Osteoarthritis: eases joint pain and improves mobility.
  • Rheumatoid arthritis: diminishes joint swelling and discomfort.
  • Acute musculoskeletal pain: provides rapid localized pain relief.
  • Soft‑tissue injuries (sprains, strains, tendinitis): reduces inflammation and supports functional recovery.

How It Works

  • Ketoprofen inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain, and fever. By limiting prostaglandin production at the site of application, the drug lowers local inflammatory responses and alleviates nociceptive signals, resulting in reduced pain and swelling.

Side Effects

Ketonal may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Skin irritation at the application site.
  • Redness or erythema.
  • Itching or mild rash.
  • Dryness of the treated area.
  • Burning sensation.
  • Localized swelling.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis) with difficulty breathing.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Significant skin ulceration or necrosis.
  • Systemic NSAID toxicity (e.g., gastrointestinal bleeding) if absorbed in large amounts.
  • Renal impairment in susceptible individuals.
  • Cardiovascular events such as myocardial infarction or stroke.

Precautions & Warnings

Before using Ketonal, consider the following safety measures.

  • Contraindications: Do not use in patients with known hypersensitivity to ketoprofen or other NSAIDs.
  • Gastrointestinal risk: Avoid in individuals with active peptic ulcer disease or recent GI bleeding.
  • Cardiovascular caution: Use cautiously in patients with a history of heart disease or hypertension.
  • Renal and hepatic function: Monitor patients with impaired kidney or liver function.
  • Pregnancy and lactation: Discuss risks with a healthcare professional before use.
  • Store below 25°C: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Ketonal can affect the safety or efficacy of several other medicines.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal and renal toxicity.
  • High‑dose aspirin: additive platelet inhibition leading to bleeding.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal function, especially in dehydrated patients.
  • Diuretics: potential for reduced kidney perfusion.
  • Lithium: NSAIDs can raise lithium serum levels, requiring monitoring.

Frequently Asked Questions

Ketonal is a topical formulation of ketoprofen, an NSAID used to relieve pain and reduce inflammation in musculoskeletal conditions such as osteoarthritis, rheumatoid arthritis, sprains, strains, and other soft‑tissue injuries. It provides localized symptom control when applied to the affected skin area.

Ketoprofen blocks the activity of cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for producing prostaglandins. By lowering prostaglandin levels at the site of application, the drug diminishes the inflammatory cascade, reduces swelling, and lessens the transmission of pain signals.

The appropriate amount of Ketonal is determined by the prescribing healthcare professional based on the patient’s condition, age, and response. The prescriber will specify the quantity of gel or cream to apply, the frequency of application, and the duration of therapy.

Safety of topical ketoprofen during pregnancy or lactation has not been fully established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their physician before using Ketonal.

To request Ketonal, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Ketonal contains ketoprofen, which offers a broad COX‑1/COX‑2 inhibition profile. Compared with diclofenac or ibuprofen gels, ketoprofen may provide faster onset of pain relief for some patients, but individual response varies. Choice of product should consider efficacy, tolerability, and physician recommendation.

Ketonal should be stored below 25 °C in its original container, protected from moisture, direct sunlight, and excessive heat. Keep the packaging sealed when not in use to maintain product stability and prevent contamination.

Ketonal is applied topically to clean, dry skin over the affected area. The prescriber will advise the amount (e.g., a thin film or specific dose) and frequency, typically 2‑4 times daily. Hands should be washed after application, and the treated area should not be covered with occlusive dressings unless directed.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, toxic epidermal necrolysis, and systemic NSAID toxicity leading to gastrointestinal bleeding, renal impairment, or cardiovascular events. Patients should seek immediate medical attention if they notice signs of a serious reaction.

Ketonal should be avoided by individuals with known hypersensitivity to ketoprofen or any NSAID, those with active gastrointestinal ulceration, severe heart failure, uncontrolled hypertension, or significant renal or hepatic impairment unless specifically directed by a physician.

Reviewed by

Dr. Shweta Ashok More

M.Pharm (Quality Assurance), Ph.D. (Medicinal Chemistry)

Content approved 18 Aug 2026

Last updated:

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