Product image of Ketonal (Ketoprofen) supplied by GNH India

Ketonal

Active Ingredient:
Ketoprofen
Origin:
EU

Ketonal (Ketoprofen)

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a topical formulation for external use. It is used to relieve pain and reduce inflammation in musculoskeletal tissues, particularly in adults with acute or chronic conditions.

GNH India supplies Ketonal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz Gmbh

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Indications & Clinical Uses

Ketonal (ketoprofen) acts on inflammatory pathways of the musculoskeletal system, providing analgesic and anti‑inflammatory effects.

  • Osteoarthritis: reduces joint pain and swelling, improving mobility.
  • Rheumatoid arthritis: alleviates chronic joint inflammation and discomfort.
  • Musculoskeletal injuries: provides symptomatic relief of pain, bruising and localized inflammation.

How It Works

  • Ketoprofen reversibly inhibits cyclooxygenase‑1 and cyclooxygenase‑2 (COX‑1/COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin synthesis limits inflammation, pain signaling, and fever responses at the site of application, producing its therapeutic effect when applied topically.

Side Effects

Ketonal may cause a range of skin‑related and systemic reactions.

Common Side Effects

  • Local skin irritation: redness, itching, or burning at the application site.
  • Dryness or peeling of the skin.
  • Mild headache.
  • Gastro‑intestinal discomfort when absorbed systemically.
  • Dizziness.

Serious or Rare Side Effects

  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatotoxicity: elevated liver enzymes or jaundice.
  • Renal impairment: reduced kidney function or acute failure.
  • Gastro‑intestinal ulceration or bleeding.
  • Cardiovascular events: increased risk of heart attack or stroke.

Precautions & Warnings

When considering Ketonal, several safety measures should be observed.

  • Assess renal function: avoid or adjust use in patients with significant kidney disease.
  • Monitor hepatic function: contraindicated in severe liver impairment.
  • Avoid in known NSAID hypersensitivity: discontinue immediately if reactions occur.
  • Use the lowest effective dose: limit duration to reduce gastrointestinal risk.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Ketonal can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Selective COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Lithium: potential rise in serum lithium concentrations.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: possible reduction in renal function.
  • Diuretics: heightened risk of renal impairment.
  • Methotrexate: decreased clearance leading to toxicity.

Frequently Asked Questions

Ketonal contains ketoprofen, a topical NSAID indicated for the relief of pain and reduction of inflammation in musculoskeletal conditions such as osteoarthritis, rheumatoid arthritis, and soft‑tissue injuries. It is applied directly to the affected skin area to provide localized symptom control.

Ketoprofen blocks the activity of cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for the production of prostaglandins. By lowering prostaglandin levels, it diminishes inflammation, pain signaling, and swelling at the site where the gel or cream is applied.

The appropriate dose of Ketonal is determined by the prescribing healthcare professional based on the patient’s condition, age, and response. The prescriber will specify the amount to apply, frequency, and duration of treatment on the product label or prescription.

Safety data for topical ketoprofen in pregnancy and lactation are limited. Because systemic absorption can occur, it is generally advised to avoid use unless the potential benefit outweighs the risk, and only under medical supervision.

To request Ketonal, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Ketonal, as a topical ketoprofen formulation, delivers the anti‑inflammatory effect directly to the skin, potentially reducing systemic exposure compared with oral NSAIDs. This can lower the risk of gastrointestinal and cardiovascular side effects, though local skin reactions may be more common.

Ketonal should be stored at room temperature, below 25 °C, in its original packaging. Protect it from moisture, direct sunlight, and extreme temperatures to maintain product stability and potency.

Ketonal is applied topically to clean, dry skin over the painful or inflamed area. The prescriber will advise the amount (e.g., a thin film or specific pea‑size amount) and frequency, typically 2‑4 times daily, avoiding broken skin or mucous membranes.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, liver toxicity, kidney impairment, gastrointestinal ulceration or bleeding, and increased cardiovascular events. Patients should seek immediate medical attention if they experience signs of these conditions.

Ketonal should be avoided in individuals with known hypersensitivity to ketoprofen or other NSAIDs, those with active gastrointestinal ulcers, severe liver or kidney disease, and patients on anticoagulant therapy where bleeding risk is high, unless a healthcare professional determines it is safe.

Reviewed by

Dr. Shweta Ashok More

M.Pharm (Quality Assurance), Ph.D. (Medicinal Chemistry)

Content approved 18 Aug 2026

Last updated:

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