Product image of Ketonal (Ketoprofen) supplied by GNH India

Ketonal

Active Ingredient:
Ketoprofen
Origin:
EU

Ketonal (Ketoprofen)

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti‑inflammatory drug presented as a topical preparation for cutaneous use. It is employed to relieve pain and reduce inflammation in musculoskeletal conditions, arthritis, sprains, strains and other localized inflammatory disorders.

GNH India supplies Ketonal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lek Pharmaceuticals D.D. Ljubljana

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Indications & Clinical Uses

Ketoprofen acts on inflammatory pathways to provide analgesic and anti‑inflammatory effects in several musculoskeletal conditions.

  • Musculoskeletal pain: reduces pain intensity and improves mobility.
  • Osteoarthritis and rheumatoid arthritis: diminishes joint swelling and stiffness.
  • Sprains and strains: alleviates localized inflammation and discomfort.
  • Localized inflammatory conditions: limits prostaglandin‑mediated swelling and erythema.

How It Works

  • Ketoprofen non‑selectively inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin synthesis leads to lower inflammation, pain signalling, and fever responses at the site of application.

Side Effects

Ketoprofen may cause a range of adverse reactions, from mild skin irritation to serious systemic events.

Common Side Effects

  • Skin irritation: redness, itching, or burning at the application site.
  • Headache: mild to moderate intensity.
  • Gastrointestinal discomfort: nausea or dyspepsia.

Serious or Rare Side Effects

  • Severe allergic reaction: angio‑edema, anaphylaxis, or Stevens‑Johnson syndrome.
  • Hepatic toxicity: elevated liver enzymes or hepatitis.
  • Renal impairment: reduced kidney function or acute renal failure.
  • Blood disorders: thrombocytopenia or leukopenia.

Precautions & Warnings

When using Ketonal, consider the following safety measures.

  • Gastro‑intestinal risk: assess history of ulcers or bleeding before use.
  • Hypersensitivity: avoid if known allergy to ketoprofen or other NSAIDs.
  • Renal/hepatic function: use with caution in patients with impaired kidney or liver function.
  • Blood pressure: monitor in individuals with hypertension.
  • Concomitant anticoagulants: evaluate bleeding risk when combined with warfarin or similar agents.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ketonal can interact with several drug classes, influencing safety and efficacy.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Systemic corticosteroids: heightened ulcer risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in renal function.
  • Diuretics: may impair kidney clearance.
  • Lithium: risk of lithium toxicity.
  • Methotrexate: enhanced hematologic toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): increased bleeding tendency.

Frequently Asked Questions

Ketonal contains ketoprofen and is applied to the skin to relieve pain and inflammation associated with musculoskeletal disorders, various forms of arthritis, sprains, strains and other localized inflammatory conditions.

Ketoprofen blocks both COX‑1 and COX‑2 enzymes, which reduces the production of prostaglandins—molecules that trigger inflammation, pain and fever. Lower prostaglandin levels lead to decreased swelling and discomfort at the site of application.

The specific dose and frequency of Ketonal are determined by the prescribing healthcare professional based on the patient’s condition, age, weight and response to therapy. Patients should follow the prescriber’s instructions and the product label.

Safety data for topical ketoprofen in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Ketonal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketonal (ketoprofen) is a non‑selective NSAID similar to ibuprofen or diclofenac but may offer stronger anti‑inflammatory effects for certain topical applications. Choice of NSAID depends on the clinical situation, patient tolerance, and physician preference.

Ketonal should be stored at room temperature, below 25 °C, in its original container. Keep it away from moisture, direct sunlight and sources of heat to maintain product stability.

Ketonal is applied topically to the affected skin area. The prescribed amount is spread thinly and gently massaged into the skin, usually one to several times daily, as directed by the healthcare professional.

Serious risks include severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, liver toxicity, renal impairment, and blood disorders like thrombocytopenia. Immediate medical attention is required if any of these symptoms appear.

Ketonal should be avoided by individuals with known hypersensitivity to ketoprofen or other NSAIDs, those with active gastrointestinal ulcers, severe renal or hepatic disease, and patients taking anticoagulants or other NSAIDs without medical supervision.

Reviewed by

Dr. Shweta Ashok More

M.Pharm (Quality Assurance), Ph.D. (Medicinal Chemistry)

Content approved 18 Aug 2026

Last updated:

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