Product image of Ketonal (Ketoprofen) supplied by GNH India

Ketonal

Active Ingredient:
Ketoprofen
Origin:
EU

Ketonal (Ketoprofen)

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti-inflammatory drug presented as an injectable solution for intramuscular, intravenous use. It treats pain and inflammation in adult patients with musculoskeletal and arthritic conditions.

GNH India supplies Ketonal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz D.O.O.

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Indications & Clinical Uses

Ketoprofen acts as an NSAID to relieve pain and inflammation in several musculoskeletal and rheumatic disorders.

  • Rheumatoid arthritis: reduces joint swelling, pain and stiffness.
  • Osteoarthritis: alleviates chronic joint pain and improves mobility.
  • Acute musculoskeletal pain: provides rapid relief after injury or strain.
  • Post‑operative pain: helps control pain following surgical procedures.

How It Works

  • Ketoprofen inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels diminish inflammation, pain signaling, and fever responses, producing its analgesic and anti‑inflammatory effects.

Side Effects

Ketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort such as nausea or dyspepsia.
  • Headache or dizziness.
  • Mild skin rash or itching.
  • Elevated blood pressure.
  • Transient renal function changes.

Serious or Rare Side Effects

  • Peptic ulcer perforation or gastrointestinal bleeding.
  • Severe hypersensitivity reactions including anaphylaxis.
  • Hepatotoxicity with jaundice.
  • Thrombotic events such as myocardial infarction or stroke.
  • Severe renal impairment or acute kidney injury.

Precautions & Warnings

Ketoprofen requires careful use in several clinical situations.

  • Renal impairment: monitor kidney function and adjust therapy.
  • Cardiovascular risk: avoid in patients with recent myocardial infarction or uncontrolled hypertension.
  • Gastrointestinal history: use gastro‑protective agents if ulcer disease is present.
  • Pregnancy and lactation: assess risk‑benefit; generally avoid in the third trimester.
  • Concomitant anticoagulants: increase bleeding risk; monitor coagulation parameters.
  • Store below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Ketoprofen can interact with several drug classes, requiring vigilance.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • High‑dose aspirin: increased renal and gastric adverse effects.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function.
  • Diuretics: may impair renal perfusion.
  • Selective serotonin reuptake inhibitors (SSRIs): modest increase in bleeding tendency.

Frequently Asked Questions

Ketonal contains ketoprofen, an NSAID that is commonly prescribed to relieve pain and reduce inflammation in conditions such as rheumatoid arthritis, osteoarthritis, acute musculoskeletal injuries, and postoperative pain. It works by targeting the inflammatory pathways that cause swelling and discomfort.

Ketoprofen blocks the activity of cyclooxygenase enzymes (COX‑1 and COX‑2), which are needed to produce prostaglandins—molecules that trigger inflammation, pain, and fever. By lowering prostaglandin levels, ketoprofen diminishes the inflammatory response and the perception of pain.

The exact dose of Ketonal is determined by the prescribing clinician based on the patient’s condition, severity of symptoms, age, renal and hepatic function, and other individual factors. Healthcare professionals follow local prescribing guidelines to set the appropriate strength and frequency.

Ketoprofen is generally avoided in the third trimester of pregnancy because it may affect fetal cardiovascular development. Use during earlier stages or while breastfeeding should only occur if the prescriber judges that the potential benefits outweigh the risks. Consultation with a healthcare provider is essential.

To request Ketonal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Ketonal (ketoprofen) offers a relatively rapid onset of analgesia and strong anti‑inflammatory activity compared with some older NSAIDs like ibuprofen. Its potency is similar to diclofenac, but individual response and tolerability can vary. Choice of NSAID often depends on patient comorbidities, risk profile and clinician preference.

Ketonal should be stored below 25 °C in its original packaging, protected from moisture and direct light. Maintaining a stable room‑temperature environment helps preserve the stability of the injectable solution and prevents degradation.

Ketonal is supplied as an injectable solution for intramuscular or intravenous administration. The route, injection site, and infusion rate are determined by the prescribing clinician, who follows aseptic technique and appropriate dosing guidelines for the specific indication.

Serious risks include gastrointestinal bleeding or ulcer perforation, severe allergic reactions such as anaphylaxis, cardiovascular events like myocardial infarction or stroke, and significant renal impairment. Patients should be monitored for signs of these complications, especially if they have pre‑existing risk factors.

Ketonal is contraindicated in patients with known hypersensitivity to ketoprofen or other NSAIDs, those with active gastrointestinal bleeding, severe heart failure, or severe renal or hepatic impairment. It should also be avoided in the third trimester of pregnancy and used with caution in the elderly.

Reviewed by

Dr. Shweta Ashok More

M.Pharm (Quality Assurance), Ph.D. (Medicinal Chemistry)

Content approved 18 Aug 2026

Last updated:

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