Product image of Ketonal (Ketoprofen) supplied by GNH India

Ketonal

Active Ingredient:
Ketoprofen
Origin:
EU

Ketonal (Ketoprofen)

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an injectable solution for intramuscular and intravenous use. It treats mild to moderate pain, post‑operative pain, musculoskeletal pain, rheumatoid arthritis and osteoarthritis in adult patients.

GNH India supplies Ketonal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz Pharmaceuticals D.D.

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Indications & Clinical Uses

Ketonal (ketoprofen) is an NSAID that reduces inflammation and pain in several musculoskeletal and postoperative conditions.

  • Mild to moderate pain: provides analgesia for acute pain episodes.
  • Post‑operative pain: helps control discomfort after surgical procedures.
  • Rheumatoid arthritis: reduces joint inflammation and pain.
  • Osteoarthritis: alleviates chronic joint discomfort.
  • Musculoskeletal pain: eases strain‑related soreness and stiffness.

How It Works

  • Ketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis diminishes inflammation, lowers peripheral sensitisation, and provides analgesic relief in affected tissues.

Side Effects

Ketonal may cause a range of adverse reactions, from mild to severe. Awareness of these effects helps clinicians monitor patients appropriately.

Common Side Effects

  • Nausea or dyspepsia.
  • Headache.
  • Dizziness.
  • Injection‑site pain or erythema.
  • Diarrhoea.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Acute renal failure.
  • Hepatic dysfunction.
  • Anaphylactic reactions.
  • Thrombotic cardiovascular events.

Precautions & Warnings

Ketonal should be used with caution in patients with specific risk factors and comorbidities.

  • Renal function: monitor kidney parameters in patients with pre‑existing renal disease.
  • Gastrointestinal risk: avoid in individuals with active peptic ulcer disease or a history of serious GI bleeding.
  • Cardiovascular health: use cautiously in patients with established heart disease or hypertension.
  • Pregnancy and lactation: avoid unless clearly indicated and benefits outweigh risks.
  • Concomitant drugs: review use of other NSAIDs, anticoagulants or corticosteroids for additive toxicity.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ketonal can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs: additive gastrointestinal toxicity.
  • Corticosteroids: heightened ulcer risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal function.
  • Diuretics: potential for renal impairment.
  • Lithium: ketoprofen may raise serum lithium levels.

Frequently Asked Questions

Ketonal, containing ketoprofen, is prescribed to manage mild to moderate pain, post‑operative discomfort, musculoskeletal pain, rheumatoid arthritis and osteoarthritis. It is administered by intramuscular or intravenous injection under medical supervision.

Ketoprofen blocks both COX‑1 and COX‑2 enzymes, reducing the production of prostaglandins that mediate inflammation, pain, and fever. By lowering prostaglandin levels, it diminishes peripheral sensitisation and provides analgesic and anti‑inflammatory effects.

The specific dose and frequency of Ketonal are determined by the prescribing clinician based on the patient’s condition, severity of pain, and individual health factors. Dosage adjustments are made according to clinical response and safety considerations.

Ketonal is generally avoided during pregnancy and lactation unless the potential benefit justifies the risk. Limited data exist, and clinicians usually consider alternative therapies for pregnant or nursing individuals.

To request Ketonal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.

Ketonal (ketoprofen) offers a potent anti‑inflammatory effect comparable to ibuprofen or diclofenac, but its injectable form allows rapid onset for acute pain management. Its safety profile is similar to other non‑selective NSAIDs, with comparable gastrointestinal and cardiovascular risks.

Ketonal should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. Maintaining the cold chain preserves the stability and sterility of the injectable solution.

Ketonal is supplied as a sterile injectable solution and is given either intramuscularly or intravenously by a qualified healthcare professional. The route, volume and rate of administration are determined by the prescriber.

Serious risks include gastrointestinal bleeding or ulceration, severe skin reactions such as Stevens‑Johnson syndrome, acute renal failure, hepatic injury, anaphylaxis, and increased risk of cardiovascular thrombotic events. Prompt medical attention is required if any of these occur.

Ketonal is contraindicated in patients with known hypersensitivity to ketoprofen or other NSAIDs, active gastrointestinal ulceration, severe renal or hepatic impairment, and in individuals with established cardiovascular disease where NSAID use is discouraged. Clinicians should assess each patient’s medical history before prescribing.

Reviewed by

Dr. Shweta Ashok More

M.Pharm (Quality Assurance), Ph.D. (Medicinal Chemistry)

Content approved 18 Aug 2026

Last updated:

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