Product image of Ketonal (Ketoprofen) supplied by GNH India

Ketonal

Active Ingredient:
Ketoprofen
Origin:
EU

Ketonal (Ketoprofen)

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It treats musculoskeletal pain, dental pain, postoperative discomfort and inflammatory joint conditions in adults.
GNH India supplies Ketonal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz D.O.O.

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Indications & Clinical Uses

Ketonal, an NSAID, is employed to manage pain and inflammation across several clinical settings.

  • Musculoskeletal pain: reduces pain and swelling associated with strains, sprains and osteoarthritis.
  • Dental pain: alleviates postoperative dental discomfort and inflammatory oral conditions.
  • Post‑surgical pain: provides analgesia after minor surgical procedures.
  • Arthritis: helps control chronic joint inflammation and stiffness in rheumatoid and osteoarthritis.

How It Works

  • Ketoprofen exerts its anti‑inflammatory and analgesic actions by reversibly inhibiting cyclooxygenase (COX‑1 and COX‑2) enzymes, which decreases the synthesis of prostaglandins involved in pain, fever and inflammation. This reduction in prostaglandin levels leads to diminished sensitisation of nociceptors and lowered inflammatory responses at the site of injury.

Side Effects

Ketonal may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia or abdominal discomfort.
  • Headache or dizziness.
  • Skin rash or mild itching.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Acute renal impairment or worsening of chronic kidney disease.
  • Severe hypersensitivity reactions, including anaphylaxis or Stevens‑Johnson syndrome.

Precautions & Warnings

Before prescribing Ketonal, clinicians should evaluate patient‑specific risk factors and monitor therapy closely.

  • Assess gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding.
  • Monitor renal function: use caution in those with impaired kidney function.
  • Use the lowest effective dose for the shortest duration needed.
  • Avoid in individuals with known hypersensitivity to ketoprofen or other NSAIDs.
  • Caution when combined with anticoagulants or antiplatelet agents.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Ketonal can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Lithium: elevated lithium serum concentrations.

Moderate Interactions (Monitor Closely)

  • Diuretics and ACE inhibitors: possible reduction in renal perfusion.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.

Frequently Asked Questions

Ketonal, containing ketoprofen, is indicated for the relief of mild to moderate musculoskeletal pain, dental pain, postoperative discomfort, and the management of inflammatory joint disorders such as osteoarthritis and rheumatoid arthritis.

Ketoprofen works by inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which reduces the production of prostaglandins. Lower prostaglandin levels decrease inflammation and the sensitisation of pain receptors, resulting in analgesic and anti‑inflammatory effects.

The appropriate dose of Ketonal is determined by the prescribing healthcare professional based on the individual’s condition, age, renal function and other clinical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Ketonal is generally not recommended during pregnancy, especially in the third trimester, because NSAIDs may affect fetal cardiovascular function. It should also be used with caution while breastfeeding, as ketoprofen can be excreted in breast milk. Consultation with a healthcare provider is essential.

To order Ketonal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketonal (ketoprofen) offers analgesic and anti‑inflammatory potency comparable to ibuprofen and naproxen, but it may have a slightly higher risk of gastrointestinal irritation. Choice of NSAID often depends on individual tolerability, specific clinical indications and physician preference.

Ketonal should be stored at ambient temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Ketonal is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with meals may reduce gastrointestinal discomfort. Swallow tablets whole; do not crush or chew them.

The most serious risks include gastrointestinal bleeding or ulcer perforation, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, and acute kidney injury, particularly in patients with pre‑existing renal impairment or dehydration.

Ketonal should be avoided in individuals with known hypersensitivity to ketoprofen or other NSAIDs, active gastrointestinal ulcer disease, severe heart failure, uncontrolled hypertension, and in patients who are in the third trimester of pregnancy.

Reviewed by

Dr. Shweta Ashok More

M.Pharm (Quality Assurance), Ph.D. (Medicinal Chemistry)

Content approved 18 Aug 2026

Last updated:

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