Product image of Ketonal (Ketoprofen) supplied by GNH India

Ketonal

Active Ingredient:
Ketoprofen
Origin:
EU

Ketonal (Ketoprofen)

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti-inflammatory drug presented as an oral dosage form for oral use. It treats pain and inflammation in adults, including musculoskeletal and joint conditions.
GNH India supplies Ketonal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lek Pharmaceuticals D.D. Ljubljana

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Indications & Clinical Uses

Ketonal is an NSAID that reduces inflammation and pain in several musculoskeletal and inflammatory disorders.

  • Pain: provides relief from acute and chronic pain conditions.
  • Rheumatoid arthritis: decreases joint inflammation and stiffness.
  • Osteoarthritis: improves mobility and reduces joint discomfort.
  • Dysmenorrhea: alleviates menstrual cramps.
  • Musculoskeletal pain: eases strain‑related discomfort.

How It Works

  • Ketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels diminish inflammation, pain signaling, and fever responses throughout the body.

Side Effects

Ketonal may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash: mild erythema or itching.
  • Elevated blood pressure.
  • Mild renal function changes.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Severe liver injury or hepatitis.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Anaphylactic reaction.
  • Acute renal failure.
  • Cardiovascular thrombotic events.

Precautions & Warnings

Before prescribing Ketonal, clinicians should consider several safety measures.

  • Assess gastrointestinal risk: avoid in patients with a history of ulcers or bleeding.
  • Monitor renal function: use caution in those with impaired kidney function.
  • Evaluate cardiovascular risk: consider alternatives for patients with heart disease.
  • Avoid use in known hypersensitivity to ketoprofen or other NSAIDs.
  • Use the lowest effective dose for the shortest duration needed.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Ketonal can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleeding.
  • Lithium: elevated lithium serum levels.

Moderate Interactions (Monitor Closely)

  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Corticosteroids: increased ulcer risk.
  • Methotrexate: reduced clearance leading to toxicity.
  • Antihypertensives (e.g., ACE inhibitors, diuretics): possible renal function decline.
  • Oral hypoglycemics: potential alteration of blood glucose control.

Frequently Asked Questions

Ketonal, containing ketoprofen, is prescribed to relieve pain and reduce inflammation associated with conditions such as rheumatoid arthritis, osteoarthritis, musculoskeletal injuries, and dysmenorrhea. It helps improve mobility and comfort in patients experiencing acute or chronic inflammatory pain.

Ketoprofen blocks the activity of cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for producing prostaglandins. By lowering prostaglandin levels, it diminishes the inflammatory response, reduces pain signaling, and helps lower fever.

The specific dose of Ketonal is determined by the prescribing clinician based on the patient’s condition, age, weight, and overall health. Healthcare professionals tailor the regimen to achieve the desired therapeutic effect while minimizing risk.

Ketonal should be used only if clearly needed during pregnancy, and it is generally avoided in the third trimester because of potential fetal risks. Breastfeeding mothers should consult a healthcare provider, as ketoprofen can pass into breast milk.

To request Ketonal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketonal (ketoprofen) offers a balance of analgesic and anti‑inflammatory potency comparable to ibuprofen and naproxen, but it may have a slightly higher risk of gastrointestinal irritation. Choice of NSAID depends on individual patient tolerance, comorbidities, and physician preference.

Ketonal should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and heat sources to maintain its stability and potency.

Ketonal is taken orally, usually with a full glass of water. It can be taken with or without food, though taking it with meals may reduce gastrointestinal discomfort. Patients should follow the prescriber’s instructions regarding timing and frequency.

Serious risks include gastrointestinal bleeding or ulcer perforation, severe liver injury, allergic reactions such as Stevens‑Johnson syndrome, and cardiovascular events like heart attack or stroke. Patients should seek immediate medical attention if they notice signs of these conditions.

Ketonal is contraindicated in individuals with known hypersensitivity to ketoprofen or other NSAIDs, those with active gastrointestinal ulcers, severe heart failure, or significant renal or hepatic impairment. It should also be avoided in the third trimester of pregnancy.

Reviewed by

Dr. Shweta Ashok More

M.Pharm (Quality Assurance), Ph.D. (Medicinal Chemistry)

Content approved 18 Aug 2026

Last updated:

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