Product image of Ketonal (Ketoprofen) supplied by GNH India

Ketonal

Active Ingredient:
Ketoprofen
Origin:
EU

Ketonal (Ketoprofen)

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti-inflammatory drug presented as an oral formulation for systemic use. It is employed to relieve pain and inflammation associated with musculoskeletal conditions, arthritis and postoperative recovery in adult patients.
GNH India supplies Ketonal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

S.C. Sandoz S.R.L.

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Indications & Clinical Uses

Ketoprofen acts as an NSAID to manage pain and inflammatory disorders.

  • Rheumatoid arthritis: reduces joint pain, swelling and stiffness.
  • Osteoarthritis: alleviates chronic joint discomfort and improves mobility.
  • Musculoskeletal injuries: diminishes pain, inflammation and edema after sprains or strains.
  • Post‑operative pain: provides analgesic relief during the early recovery period.

How It Works

  • Ketoprofen inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin synthesis limits inflammation, pain signaling and fever generation, producing its analgesic and anti‑inflammatory effects throughout the body.

Side Effects

Ketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache or dizziness.
  • Mild skin rash or pruritus.
  • Elevated blood pressure in susceptible individuals.

Serious or Rare Side Effects

  • Peptic ulcer disease or gastrointestinal bleeding.
  • Renal impairment or acute kidney injury.
  • Hepatotoxicity presenting as jaundice or abnormal liver enzymes.
  • Severe hypersensitivity reactions such as Stevens‑Johnson syndrome.
  • Cardiovascular events including myocardial infarction or stroke.

Precautions & Warnings

When using Ketoprofen, consider the following safety measures.

  • Gastrointestinal risk: assess history of ulcers or bleeding before initiating therapy.
  • Renal function: monitor kidney parameters in patients with pre‑existing renal disease.
  • Cardiovascular health: use cautiously in individuals with hypertension or heart disease.
  • Concomitant drugs: avoid simultaneous use with other NSAIDs or anticoagulants without medical guidance.
  • Pregnancy and lactation: discuss risks with a healthcare professional before use.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging and protect from moisture.

Avoid Interactions

Ketoprofen can interact with several medication classes, requiring attention to dosage and monitoring.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): additive bleeding risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or diuretics: possible reduction in renal function.
  • Lithium: NSAIDs may raise lithium serum levels.
  • Methotrexate: decreased clearance leading to toxicity.

Frequently Asked Questions

Ketonal, containing ketoprofen, is prescribed to manage moderate to severe pain and inflammation caused by conditions such as rheumatoid arthritis, osteoarthritis, musculoskeletal injuries and postoperative discomfort. It works by reducing the inflammatory response, thereby alleviating pain and improving functional ability in affected joints and tissues.

Ketoprofen blocks the activity of cyclooxygenase enzymes (COX‑1 and COX‑2), which are essential for producing prostaglandins—chemical messengers that promote inflammation, pain and fever. By limiting prostaglandin synthesis, ketoprofen reduces these symptoms and helps restore normal tissue function.

The appropriate dose of Ketonal is determined by a qualified prescriber based on the patient’s specific condition, age, weight and overall health status. Healthcare professionals tailor the regimen to achieve optimal pain control while minimizing potential risks.

Ketonal should be used during pregnancy or lactation only if clearly needed and after a thorough risk‑benefit assessment by a healthcare provider. NSAIDs may affect fetal development and can pass into breast milk, so professional guidance is essential before starting therapy.

To request Ketonal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketonal (ketoprofen) offers analgesic and anti‑inflammatory potency comparable to ibuprofen and naproxen, but its longer half‑life may allow less frequent dosing for some patients. Individual response varies, and clinicians consider factors such as gastrointestinal tolerance, renal function and cardiovascular risk when selecting an NSAID.

Ketonal should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Ketonal is taken orally, usually with a full glass of water. It can be administered with or without food, although taking it with meals may reduce gastrointestinal irritation. Patients should follow the prescriber’s instructions regarding timing and frequency.

Serious risks include gastrointestinal bleeding or ulceration, severe renal impairment, hepatotoxicity, and increased cardiovascular events such as heart attack or stroke. Prompt medical attention is required if symptoms like black stools, sudden kidney dysfunction, jaundice or chest pain occur.

Ketonal is contraindicated in individuals with known hypersensitivity to ketoprofen or other NSAIDs, active peptic ulcer disease, severe heart failure, uncontrolled hypertension, and in patients who have experienced a recent myocardial infarction. It should also be avoided in those taking anticoagulants without close medical supervision.

Reviewed by

Dr. Shweta Ashok More

M.Pharm (Quality Assurance), Ph.D. (Medicinal Chemistry)

Content approved 18 Aug 2026

Last updated:

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