Product image of Ketonal (Ketoprofen) supplied by GNH India

Ketonal

Active Ingredient:
Ketoprofen
Origin:
EU

Ketonal (Ketoprofen)

Ketoprofen, the active ingredient in Ketonal, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral formulation for systemic use. It is employed to relieve pain and reduce inflammation in adult patients with musculoskeletal and inflammatory conditions.

GNH India supplies Ketonal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets. Its global distribution network ensures timely delivery and compliance with local regulatory requirements.

Manufacturer / TM Owner

Sandoz Pharmaceuticals D.D.

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Indications & Clinical Uses

Ketoprofen acts as an NSAID to modulate inflammatory pathways, providing relief in several painful and inflammatory conditions.

  • Rheumatoid arthritis: reduces joint pain, swelling and stiffness, improving functional ability.
  • Osteoarthritis: alleviates chronic joint discomfort and improves mobility.
  • Acute musculoskeletal pain: offers short‑term relief of pain and inflammation following injury or strain.
  • Dental pain: helps control postoperative pain and gingival inflammation after dental procedures.

How It Works

  • Ketoprofen inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, which decreases the synthesis of prostaglandins that mediate inflammation, pain, and fever. By reducing prostaglandin levels at sites of tissue injury, it produces analgesic, antipyretic, and anti‑inflammatory effects throughout the body.

Side Effects

Ketoprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash: mild erythema or itching.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Acute renal impairment or failure.
  • Hepatic injury or elevated liver enzymes.
  • Anaphylactic shock or severe hypersensitivity.

Precautions & Warnings

When prescribing Ketonal, clinicians should consider several safety measures.

  • Assess renal function: evaluate kidney status before initiating therapy and monitor during treatment.
  • Monitor gastrointestinal risk: avoid use in patients with a history of ulcer or bleeding.
  • Check for hypersensitivity: discontinue if allergic reactions such as rash or bronchospasm occur.
  • Use cautiously in cardiovascular disease: consider increased risk of thrombotic events.
  • Store at room temperature: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Ketonal can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Selective COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Lithium: ketoprofen may raise lithium serum concentrations.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in renal function.
  • Diuretics: heightened risk of renal impairment and electrolyte imbalance.
  • Methotrexate: reduced clearance leading to toxicity.

Frequently Asked Questions

Ketonal contains ketoprofen, an NSAID that is used to relieve mild to moderate pain and to reduce inflammation associated with conditions such as rheumatoid arthritis, osteoarthritis, acute musculoskeletal injuries, and dental postoperative discomfort.

Ketoprofen blocks the activity of cyclooxygenase enzymes (COX‑1 and COX‑2), which are required for the production of prostaglandins. By lowering prostaglandin levels, it diminishes the signals that cause pain, swelling, and fever.

The appropriate dose of Ketonal is set by the prescribing clinician based on the patient’s age, weight, severity of pain or inflammation, renal and hepatic function, and any concomitant medications. Patients should follow the prescriber’s instructions exactly.

Ketoprofen, like other NSAIDs, is generally avoided during the third trimester of pregnancy because it may affect fetal circulation. Limited data exist for use in early pregnancy and while breastfeeding; clinicians should weigh potential risks against benefits before prescribing.

To request Ketonal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Both ketoprofen and ibuprofen belong to the NSAID class and share similar mechanisms of COX inhibition. Ketoprofen often has a slightly longer half‑life, which may allow less frequent dosing, but the safety profile regarding gastrointestinal and cardiovascular risk is comparable and must be evaluated for each patient.

Ketonal should be stored at room temperature, below 25 °C, in its original container to protect it from moisture and direct sunlight. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments.

Ketonal is taken orally, usually with a full glass of water. It may be taken with food or milk to lessen stomach irritation, but patients should follow the specific instructions provided by their healthcare professional.

The most serious risks include gastrointestinal bleeding or ulcer perforation, severe skin reactions such as Stevens‑Johnson syndrome, acute kidney injury, and rare but life‑threatening allergic reactions like anaphylaxis. Patients should seek immediate medical attention if they notice signs of these conditions.

Ketonal should be avoided in individuals with known hypersensitivity to ketoprofen or other NSAIDs, those with active gastrointestinal ulcers, severe heart failure, uncontrolled hypertension, or significant renal or hepatic impairment unless specifically directed by a physician.

Reviewed by

Dr. Shweta Ashok More

M.Pharm (Quality Assurance), Ph.D. (Medicinal Chemistry)

Content approved 18 Aug 2026

Last updated:

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