Product image of Lasix 500 (Furosemide) supplied by GNH India

Lasix 500

Active Ingredient:
Furosemide
Origin:
EU

Lasix 500 (Furosemide)

Furosemide, the active ingredient in Lasix 500, is a loop diuretic presented as an oral tablet for oral use. It promotes the excretion of excess fluid and sodium, helping to manage edema and high blood pressure in patients with heart, liver, or kidney conditions.

GNH India supplies Lasix 500 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. All shipments are accompanied by full regulatory documentation to ensure compliance with local authorities.

Manufacturer / TM Owner

Sanofi B.V.

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Indications & Clinical Uses

Furosemide is used to treat conditions involving fluid overload by acting on the renal loop of Henle.

  • Congestive heart failure edema: reduces excess fluid accumulation, improving breathing and swelling.
  • Liver cirrhosis‑related edema: facilitates removal of ascitic fluid, decreasing abdominal distension.
  • Renal disease‑associated edema: enhances urinary output to manage peripheral and pulmonary edema.
  • Hypertension: lowers blood pressure by decreasing plasma volume through diuresis.

How It Works

  • Furosemide inhibits the Na⁺/K⁺/2Cl⁻ cotransporter in the thick ascending limb of the loop of Henle. Blocking this transporter reduces reabsorption of sodium, potassium, and chloride, leading to increased excretion of water together with these electrolytes. The resulting diuresis decreases extracellular fluid volume, alleviating edema and lowering systemic vascular resistance, which contributes to blood‑pressure reduction.

Side Effects

Furosemide may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Increased urination: frequent need to void.
  • Thirst: sensation of dry mouth.
  • Dizziness or light‑headedness: especially when standing quickly.
  • Electrolyte imbalance: low potassium or sodium levels.
  • Muscle cramps: due to changes in electrolyte concentrations.

Serious or Rare Side Effects

  • Severe dehydration: marked fluid loss leading to hypotension.
  • Acute kidney injury: sudden decline in renal function.
  • Ototoxicity: hearing loss or ringing in the ears, particularly with high doses.
  • Allergic reactions: rash, itching, or swelling.
  • Blood disorders: low white‑blood‑cell or platelet counts.

Precautions & Warnings

When prescribing furosemide, clinicians should consider several safety measures to minimize risks.

  • Monitor electrolytes: check serum potassium, sodium, and magnesium regularly.
  • Assess renal function: evaluate creatinine and eGFR before and during therapy.
  • Adjust dose in the elderly: start with lower doses to reduce orthostatic hypotension.
  • Caution in diabetes: monitor blood glucose as diuresis may affect control.
  • Avoid concurrent NSAIDs: they may reduce diuretic efficacy.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Furosemide can interact with other medicines, altering its effectiveness or increasing toxicity.

Major Interactions (Avoid)

  • Aminoglycoside antibiotics: may increase risk of ototoxicity.
  • Lithium: furosemide can raise lithium levels, risking toxicity.
  • High‑dose NSAIDs: can blunt diuretic response and impair renal function.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may enhance potassium loss and cause hypotension.
  • Antidiabetic drugs: diuresis may affect blood‑glucose control.
  • Corticosteroids: can potentiate fluid and electrolyte disturbances.

Frequently Asked Questions

Lasix 500 contains furosemide, a loop diuretic indicated for the treatment of edema associated with congestive heart failure, liver cirrhosis, renal disease, and for the management of hypertension. It helps remove excess fluid and sodium from the body, reducing swelling and lowering blood pressure.

Furosemide acts on the thick ascending limb of the loop of Henle in the kidney, where it blocks the Na⁺/K⁺/2Cl⁻ cotransporter. This inhibition prevents reabsorption of sodium, potassium, and chloride, leading to increased urinary excretion of water and electrolytes, which reduces fluid overload and blood‑volume.

The appropriate dose of Lasix 500 is determined by the prescribing clinician based on the patient’s medical condition, severity of edema or hypertension, renal function, and response to therapy. Dosage may be adjusted during treatment, and patients should follow the prescriber’s instructions exactly.

Safety data for furosemide in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the risks and alternatives with their healthcare provider.

To order Lasix 500, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then provides pricing, availability, shipping details and any required import documentation.

Lasix 500 (furosemide) is a loop diuretic, which is generally more potent than thiazide or potassium‑sparing diuretics for rapid fluid removal. It works on the renal loop of Henle, whereas thiazides act on the distal convoluted tubule. Choice of diuretic depends on the clinical situation, desired speed of diuresis, and patient tolerance.

Store Lasix 500 below 25 °C in its original packaging, protecting it from moisture and direct sunlight. Do not expose the tablets to excessive heat or humidity, and keep them out of reach of children.

Lasix 500 is taken orally, usually with a full glass of water. It may be taken with or without food, but consistent timing each day helps maintain stable blood levels. Patients should swallow the tablet whole and not crush or chew it unless directed by a healthcare professional.

Serious risks include severe dehydration, electrolyte disturbances (especially low potassium or sodium), acute kidney injury, and ototoxicity such as hearing loss or tinnitus. Patients should report sudden dizziness, fainting, rapid weight loss, hearing changes, or reduced urine output to their clinician promptly.

Lasix 500 should be avoided in patients with known hypersensitivity to furosemide or other sulfonamide drugs, those with anuria (no urine output), or severe electrolyte depletion. Caution is also advised for individuals with severe liver disease, uncontrolled diabetes, or those taking interacting medications without close monitoring.

Reviewed by

Dr. Shweta Ashok More

M.Pharm (Quality Assurance), Ph.D. (Medicinal Chemistry)

Content approved 26 Aug 2026

Last updated:

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