Product image of Lenalidomide Sandoz 7.5 Mg Hard Capsules (Lenalidomide) supplied by GNH India

Lenalidomide Sandoz 7.5 Mg Hard Capsules

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Sandoz 7.5 Mg Hard Capsules (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Sandoz 7.5 mg Hard Capsules, is an immunomodulatory agent presented as a 7.5 mg hard capsule for oral use. It is indicated for the treatment of adult patients with multiple myeloma and for myelodysplastic syndromes that carry the del(5q) chromosomal abnormality.

GNH India supplies Lenalidomide Sandoz 7.5 mg Hard Capsules as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for global distribution.

Manufacturer / TM Owner

Sandoz Ltd

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Indications & Clinical Uses

Lenalidomide is an immunomodulatory agent used in hematologic malignancies and related bone‑marrow disorders.

  • Multiple myeloma: improves progression‑free survival and overall response rates in newly diagnosed or relapsed disease.
  • Myelodysplastic syndromes with del(5q): reduces transfusion dependence and can lead to cytogenetic remission.
  • Relapsed or refractory multiple myeloma: provides an additional therapeutic option after prior treatments have failed.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4 E3 ubiquitin ligase complex, prompting the ubiquitination and proteasomal degradation of transcription factors Ikaros (IKZF1) and Aiolos (IKZF3). This results in modulation of the immune microenvironment, inhibition of angiogenesis, and direct anti‑myeloma activity through apoptosis and cell‑cycle arrest.

Side Effects

Lenalidomide may cause a range of adverse reactions, which are typically categorized by frequency and severity.

Common Side Effects

  • Neutropenia: reduced neutrophil count leading to infection risk.
  • Thrombocytopenia: low platelet count increasing bleeding tendency.
  • Fatigue: persistent tiredness affecting daily activities.
  • Nausea: upset stomach often mild to moderate.

Serious or Rare Side Effects

  • Deep vein thrombosis or pulmonary embolism: clot formation in veins or lungs.
  • Severe skin reactions (Stevens‑Johnson syndrome): extensive rash with mucosal involvement.
  • Secondary primary malignancies: emergence of new cancers during therapy.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate specific safety considerations.

  • Pregnancy: contraindicated (Category X); avoid use in pregnant women and ensure effective contraception.
  • Thromboembolic risk: assess patient history and consider prophylactic anticoagulation when risk is high.
  • Renal impairment: dose adjustment may be required based on measured renal function.
  • Hematologic monitoring: perform regular complete blood counts to detect neutropenia or thrombocytopenia.
  • Store at ambient temperature: keep below 25 °C, retain in the original packaging, and protect from moisture.

Avoid Interactions

Lenalidomide can interact with several concomitant medicines; interactions are grouped by clinical significance.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may markedly reduce lenalidomide exposure.
  • Anticoagulants (e.g., warfarin) combined with lenalidomide in high‑risk patients: increased risk of thromboembolic events.

Moderate Interactions (Monitor Closely)

  • Antiplatelet agents (e.g., aspirin): may increase bleeding risk.
  • NSAIDs: may exacerbate thrombocytopenia.
  • P‑glycoprotein inhibitors (e.g., verapamil): may modestly increase plasma levels of lenalidomide.

Frequently Asked Questions

Lenalidomide Sandoz 7.5 mg Hard Capsules are prescribed for adult patients with multiple myeloma and for myelodysplastic syndromes that carry the del(5q) chromosomal abnormality. The drug helps control disease progression, improve blood counts, and reduce the need for transfusions in these hematologic conditions.

Lenalidomide binds to cereblon, a component of the CRL4 E3 ubiquitin ligase complex, leading to the degradation of transcription factors Ikaros and Aiolos. This action modifies the immune response, inhibits new blood‑vessel formation, and triggers apoptosis of malignant plasma cells, providing anti‑myeloma activity.

The specific dose of Lenalidomide Sandoz 7.5 mg is determined by the treating physician based on the patient’s diagnosis, disease stage, renal function, and prior therapies. Clinicians tailor the regimen to achieve optimal efficacy while monitoring safety, and patients should follow the prescriber’s instructions exactly.

Lenalidomide is classified as Pregnancy Category X, meaning it is contraindicated in pregnant women because it can cause fetal harm. Women of child‑bearing potential must use effective contraception during treatment and for a defined period after the last dose. Breastfeeding is not recommended while taking lenalidomide.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and assistance with import documentation.

Lenalidomide belongs to the immunomodulatory drug (IMiD) class, sharing a mechanism with thalidomide and pomalidomide. Compared with thalidomide, lenalidomide generally offers a more favorable side‑effect profile, especially regarding neuropathy, while providing comparable anti‑myeloma efficacy. Pomalidomide may be used after lenalidomide failure, offering an additional option for resistant disease.

Store the capsules at ambient temperature, preferably below 25 °C (77 °F). Keep them in the original blister pack or container to protect from moisture and light. Do not refrigerate or freeze the product, and keep it out of reach of children.

Lenalidomide is taken orally as a hard capsule with a full glass of water. It may be taken with or without food, but patients should follow the prescriber’s guidance regarding timing relative to meals. Capsules should be swallowed whole and not opened, crushed, or chewed.

Serious risks include severe neutropenia and thrombocytopenia, which can lead to infection or bleeding; deep‑vein thrombosis or pulmonary embolism; life‑threatening skin reactions such as Stevens‑Johnson syndrome; and the potential development of secondary primary malignancies. Patients should report any signs of infection, unusual bruising, swelling of limbs, or severe rash promptly.

Lenalidomide should not be used by pregnant women or women who could become pregnant without effective contraception. It is also contraindicated in patients with known hypersensitivity to lenalidomide or any component of the formulation. Caution is advised for individuals with severe renal impairment, uncontrolled infections, or a history of thromboembolic events.

Reviewed by

Dr. Shweta Ashok More

M.Pharm (Quality Assurance), Ph.D. (Medicinal Chemistry)

Content approved 25 Aug 2026

Last updated:

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