Product image of Lisdexamfetamine dimesylate 40 mg/1 (Lisdexamfetamine dimesylate) 40 mg/1 CAPSULE supplied by GNH India

Lisdexamfetamine dimesylate 40 mg/1

Active Ingredient:
Lisdexamfetamine dimesylate
Form:
CAPSULE
Brand:
Lisdexamfetamine dimesylate
Origin:
USA

Lisdexamfetamine dimesylate 40 mg/1 (Lisdexamfetamine dimesylate CAPSULE) 40 mg/1

Lisdexamfetamine dimesylate, the active ingredient in Lisdexamfetamine dimesylate 40 mg/1, is a central nervous system (CNS) stimulant presented as a 40 mg capsule for oral use. It is indicated for the treatment of attention deficit hyperactivity disorder (ADHD) in adults and pediatric patients 6 years and older, as well as for moderate to severe binge eating disorder (BED) in adults.

GNH India supplies Lisdexamfetamine dimesylate 40 mg/1 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Strength

40 mg/1

Pack Size

100 CAPSULE in 1 BOTTLE (0781-2478-01)

Manufacturer / TM Owner

Sandoz Inc

1
Pack/s
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Indications & Clinical Uses

Lisdexamfetamine dimesylate 40 mg/1 is a CNS stimulant used to manage conditions related to attention and eating disorders.

  • Attention Deficit Hyperactivity Disorder (ADHD): Helps improve focus, attention, and reduce hyperactivity in adults and children aged 6 and older.
  • Binge Eating Disorder (BED): Reduces the frequency of binge eating episodes in adults with moderate to severe BED.
  • ADHD in Pediatric Patients: Specifically formulated to aid in the treatment of ADHD symptoms in children aged 6 and older.

How It Works

  • Lisdexamfetamine dimesylate is a prodrug of dextroamphetamine. It increases the release of norepinephrine and dopamine in the central nervous system, which helps to improve attention and control behavior in individuals with ADHD. It also helps to reduce binge eating episodes by modulating these neurotransmitters.

Side Effects

Lisdexamfetamine dimesylate 40 mg/1 can cause various side effects, ranging from common to serious.

Common Side Effects

  • Decreased appetite
  • Dry mouth
  • Insomnia
  • Anxiety
  • Nausea
  • Dizziness
  • Irritability
  • Increased heart rate

Serious or Rare Side Effects

  • Heart problems, including increased blood pressure and heart rate
  • Psychiatric problems, including new or worsening aggression, mania, or psychosis
  • Seizures
  • Peripheral vasculopathy, including Raynaud’s phenomenon
  • Serotonin syndrome, particularly when taken with other serotonergic drugs

Precautions & Warnings

Lisdexamfetamine dimesylate 40 mg/1 should be used with caution and under medical supervision.

  • Prescription Use: Only use as prescribed by a healthcare provider.
  • Cardiovascular Conditions: Avoid in patients with serious heart conditions.
  • Mental Health Conditions: Monitor for worsening of behavioral or mental health conditions.
  • Substance Abuse: Has a potential for abuse and dependence.
  • Pregnancy: Should be used during pregnancy only if clearly needed.
  • Breastfeeding: Discuss with a healthcare provider before use while breastfeeding.
  • Store at room temperature: Keep in a safe place, away from light and moisture, and out of reach of children.

Avoid Interactions

Lisdexamfetamine dimesylate 40 mg/1 can interact with other medications, potentially affecting its efficacy or increasing the risk of side effects.

Major Interactions (Avoid)

  • Monoamine Oxidase Inhibitors (MAOIs): Can cause dangerous increases in blood pressure.
  • Other Stimulants: May increase the risk of serious side effects.
  • Antidepressants: Particularly those that increase serotonin levels, which can lead to serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: May reduce the effectiveness of blood pressure medications.
  • Acidifying or Alkalizing Agents: Can affect the absorption and effectiveness of lisdexamfetamine.
  • Antipsychotics: May reduce the effectiveness of lisdexamfetamine.

Frequently Asked Questions

Lisdexamfetamine dimesylate 40 mg/1 is a central nervous system (CNS) stimulant used to treat attention deficit hyperactivity disorder (ADHD) in adults and children aged 6 and older, as well as moderate to severe binge eating disorder (BED) in adults. It helps improve focus, attention, and reduce hyperactivity in ADHD patients and reduces the frequency of binge eating episodes in individuals with BED.

Lisdexamfetamine dimesylate is a prodrug of dextroamphetamine. It works by increasing the release of norepinephrine and dopamine in the central nervous system. These neurotransmitters help improve attention and control behavior in individuals with ADHD and reduce binge eating episodes by modulating these neurotransmitters.

The recommended starting dosage of Lisdexamfetamine dimesylate 40 mg/1 is 30 mg once daily in the morning for both adults and pediatric patients 6 years and older. The dosage may be adjusted in increments of 10 mg or 20 mg at approximately weekly intervals up to a maximum recommended dosage of 70 mg once daily. The prescriber will determine the appropriate dosage based on individual patient needs.

Lisdexamfetamine dimesylate should be used during pregnancy only if clearly needed, as it falls under pregnancy category C. This means that animal reproduction studies have shown an adverse effect on the fetus, and there are no adequate and well-controlled studies in humans. For breastfeeding, it is important to discuss with a healthcare provider before use, as the drug may pass into breast milk.

To order Lisdexamfetamine dimesylate 40 mg/1 from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will then provide pricing, availability, shipping details, and the necessary import paperwork.

Lisdexamfetamine dimesylate is a prodrug that is converted into dextroamphetamine in the body, providing a longer-lasting effect compared to some other stimulants. It is often preferred for its once-daily dosing and prolonged duration of action. However, the choice of medication depends on individual patient response, side effect profile, and specific clinical needs, which should be discussed with a healthcare provider.

Lisdexamfetamine dimesylate 40 mg/1 should be stored at room temperature between 68°F to 77°F (20°C to 25°C). It can be exposed to temperatures between 59°F to 86°F (15°C to 30°C) for shorter periods. Store it in a cool, dry, and safe place like a locked cabinet, in a tightly closed container, and protect it from light. Keep it out of reach of children and pets.

Lisdexamfetamine dimesylate 40 mg/1 is administered orally, typically once daily in the morning. The capsules can be swallowed whole with water or the contents can be sprinkled on a small amount of applesauce, yogurt, or other similar foods. It is important to follow the prescribing information and instructions provided by the healthcare provider.

The most serious risks associated with Lisdexamfetamine dimesylate include heart problems such as increased blood pressure and heart rate, psychiatric problems like new or worsening aggression, mania, or psychosis, seizures, and peripheral vasculopathy, including Raynaud’s phenomenon. It also has the potential for abuse and dependence. Patients should be monitored closely for these risks.

Lisdexamfetamine dimesylate 40 mg/1 should not be used by individuals with serious heart conditions, such as heart disease, heart defect, or high blood pressure. It is also not recommended for those with severe anxiety, agitation, or a history of drug abuse. Patients with glaucoma, overactive thyroid, or a history of seizures should use it with caution. Always consult a healthcare provider before starting this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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