Product image of Luxturna 5000000000000 Vg (Voretigene Neparvovec) 5000000000000 VG SOLUTION supplied by GNH India

Luxturna 5000000000000 Vg

Active Ingredient:
Voretigene Neparvovec
Form:
SOLUTION
Brand:
LUXTURNA
Origin:
CANADA

Luxturna 5000000000000 Vg (Voretigene Neparvovec SOLUTION) 5000000000000 VG

Voretigene neparvovec, the active ingredient in Luxturna 5000000000000 Vg, is a gene therapy presented as a 5,000,000,000,000 vg solution for subretinal use. It is indicated for the treatment of vision loss due to inherited retinal dystrophy caused by mutations in the RPE65 gene in adults and children. GNH India supplies Luxturna 5000000000000 Vg as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Luxturna is a groundbreaking gene therapy designed to address genetic disorders affecting vision. It is specifically formulated to deliver a functional copy of the RPE65 gene to retinal cells, thereby restoring vision in patients with specific genetic mutations.

Strength

5000000000000 VG

Manufacturer / TM Owner

NOVARTIS PHARMACEUTICALS CANADA INC

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Luxturna is used in the treatment of inherited retinal dystrophy caused by mutations in the RPE65 gene. This condition leads to progressive vision loss and, in many cases, blindness. The therapy is designed to deliver a functional copy of the RPE65 gene to retinal cells, thereby restoring vision.

  • RPE65-mediated inherited retinal dystrophy: Restores vision in patients with this genetic condition.
  • Biallelic RPE65 mutation-associated retinal dystrophy: Improves visual function and potentially slows further vision loss.
  • Leber congenital amaurosis type 2: Enhances visual cycle and improves visual acuity.

How It Works

  • Luxturna works by delivering a functional copy of the RPE65 gene to retinal pigment epithelial cells via an adeno-associated virus (AAV) vector. This gene therapy restores the visual cycle in patients with biallelic RPE65 mutations, enabling the production of proteins necessary for vision. The therapy targets the retina, the light-sensing layer at the back of the eye, and helps in the resumption of the visual cycle, which is crucial for vision.

Side Effects

Luxturna may cause several side effects, ranging from common to serious. It is important to be aware of these potential effects and to consult with a healthcare provider if any adverse reactions occur.

Common Side Effects

  • Redness of the eye
  • Eye swelling or pain
  • Clouding of the lens of the eye (cataract)
  • Increased pressure inside the eye
  • Eye infections
  • Retinal detachment
  • Bleeding in the retina
  • Permanent decline in the sharpness of your vision
  • Thinning of the retina or loss of function
  • Breaks or wrinkling on the surface of your retina
  • Deposits under your retina
  • Thinning of the clear layer in front of your eye
  • New or worsening cataract

Precautions & Warnings

Luxturna should be used with caution and under the supervision of a healthcare provider. Certain precautions and warnings should be observed to ensure safe and effective use.

  • Avoid air travel or other travel to high elevations: Until advised by your doctor, as the air bubble inserted during treatment may expand and lead to eye damage.
  • Follow-up visits: Important to return for follow-up visits to identify and treat any side effects.
  • Eye surgery: Required before receiving Luxturna, which may lead to complications such as cataracts.
  • Subretinal injection: Should not be administered in the immediate vicinity of the fovea to maintain foveal integrity.
  • Store at ≤-65 ºC: Once thawed, the medicine should not be re-frozen and should be left at room temperature (below 25 °C).

Avoid Interactions

Luxturna may interact with other medications or conditions, which can affect its efficacy or increase the risk of side effects. It is important to discuss all current medications and health conditions with a healthcare provider before starting Luxturna.

Major Interactions (Avoid)

  • None identified

Moderate Interactions (Monitor Closely)

  • None identified

Frequently Asked Questions

Luxturna is used for the treatment of vision loss due to inherited retinal dystrophy caused by mutations in the RPE65 gene. It is specifically designed to deliver a functional copy of the RPE65 gene to retinal cells, thereby restoring vision in patients with this genetic condition.

Voretigene neparvovec works by delivering a functional copy of the RPE65 gene to retinal pigment epithelial cells via an adeno-associated virus (AAV) vector. This gene therapy restores the visual cycle in patients with biallelic RPE65 mutations, enabling the production of proteins necessary for vision.

The dose of Luxturna is determined by a healthcare provider based on the patient's specific condition and needs. It is administered as a subretinal injection after vitrectomy in each eye. The exact dosage and administration schedule should be discussed with a healthcare professional.

The safety of Luxturna during pregnancy or breastfeeding has not been established. It is important to consult with a healthcare provider to discuss the potential risks and benefits before using Luxturna in these situations.

To order Luxturna from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will reply with pricing, availability, shipping, and the import paperwork.

Luxturna is a pioneering gene therapy that offers a unique approach to treating inherited retinal dystrophy by directly addressing the genetic mutation. Unlike other treatments that may only manage symptoms, Luxturna aims to restore vision by delivering a functional copy of the RPE65 gene to retinal cells.

Luxturna should be stored and transported frozen at ≤-65 ºC. Once thawed, the medicine should not be re-frozen and should be left at room temperature (below 25 °C). It is important to follow the storage instructions provided by the healthcare professional to ensure the efficacy and safety of the medication.

Luxturna is administered as a subretinal injection after vitrectomy in each eye. The procedure is performed by a specialist in ophthalmology. The injection is given directly under the retina, the thin light-sensing layer at the back of the eye. The injections will happen one eye at a time, on two different dates separated by at least six days.

The most serious risks associated with Luxturna include retinal detachment, bleeding in the retina, and permanent decline in the sharpness of vision. Patients should be monitored for any signs of these complications and should seek immediate medical attention if they experience any adverse effects.

Luxturna is not suitable for everyone. Patients who do not have mutations in the RPE65 gene or who do not have sufficient viable retinal cells may not benefit from this treatment. It is important to undergo genetic testing to confirm eligibility for Luxturna. Additionally, patients with certain eye conditions or allergies to any of the components of Luxturna should avoid using this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.