Product image of Meralys 0,5 Mg/Ml (Xylometazoline Hydrochloride) supplied by GNH India

Meralys 0,5 Mg/Ml

Active Ingredient:
Xylometazoline Hydrochloride
Origin:
EU

Meralys 0,5 Mg/Ml (Xylometazoline Hydrochloride)

Xylometazoline Hydrochloride, the active ingredient in Meralys 0,5 Mg/Ml, is a alpha‑adrenergic agonist presented as a 0.5 mg/mL nasal solution for nasal use. It relieves nasal congestion associated with the common cold, sinusitis, and allergic rhinitis in both adults and children.

GNH India supplies Meralys 0,5 Mg/Ml as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Jadran-Galenski Laboratorij D.D.

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Indications & Clinical Uses

Xylometazoline Hydrochloride is a topical nasal decongestant that reduces swelling of the nasal mucosa.

  • Common cold: alleviates nasal congestion by reducing mucosal edema.
  • Sinusitis: improves nasal airflow and relieves sinus pressure.
  • Allergic rhinitis: decreases nasal blockage caused by allergic inflammation.

How It Works

  • Xylometazoline Hydrochloride acts as a selective alpha‑adrenergic agonist on the smooth muscle of nasal blood vessels. Activation of alpha‑1 receptors induces vasoconstriction, which diminishes blood flow to the nasal mucosa, thereby reducing edema and opening the airway for easier breathing.

Side Effects

Xylometazoline Hydrochloride may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nasal irritation: mild burning or stinging sensation.
  • Sneezing: transient increase in sneezing episodes.
  • Dryness: nasal mucosa dryness or crusting.
  • Headache: mild headache.

Serious or Rare Side Effects

  • Rebound congestion: worsening nasal blockage after prolonged use.
  • Hypertension: elevated blood pressure in susceptible individuals.
  • Cardiac arrhythmia: irregular heartbeat (rare).

Precautions & Warnings

When using Xylometazoline Hydrochloride nasal solution, certain precautions should be observed to ensure safety and effectiveness.

  • Duration of use: limit to no more than 3‑5 consecutive days to avoid rebound congestion.
  • Underlying conditions: avoid in patients with severe hypertension or coronary artery disease without medical advice.
  • Age restrictions: not recommended for children under 6 years unless directed by a healthcare professional.
  • Pregnancy and lactation: use only if clearly needed and prescribed by a physician.
  • Drug interactions: consult a clinician before combining with other nasal decongestants or sympathomimetic agents.
  • Store at ambient temperature: keep below 25°C, retain in original container, protect from moisture and direct sunlight.

Avoid Interactions

Xylometazoline Hydrochloride can interact with certain medications, affecting its safety profile.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): concurrent use may increase risk of hypertensive crisis.
  • Other nasal decongestants: combined vasoconstriction can cause excessive blood pressure rise.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: may reduce effectiveness of blood pressure control.
  • Tricyclic antidepressants: potential additive sympathomimetic effects.
  • Beta‑blockers: may blunt cardiovascular response, requiring monitoring.

Frequently Asked Questions

Meralys 0,5 Mg/Ml is a nasal spray containing Xylometazoline Hydrochloride, indicated for the temporary relief of nasal congestion caused by the common cold, sinusitis, and allergic rhinitis. It works by narrowing the blood vessels in the nasal passages, which reduces swelling and improves airflow.

Xylometazoline Hydrochloride is a selective alpha‑adrenergic agonist. When applied to the nasal mucosa, it stimulates alpha‑1 receptors on the blood vessels, causing vasoconstriction. This reduces blood flow and edema in the nasal lining, leading to decreased congestion and easier breathing.

The specific dosing regimen for Meralys 0,5 Mg/Ml is determined by the prescribing healthcare professional based on the patient’s age, condition, and response to therapy. Typical instructions involve a few sprays per nostril, not exceeding the recommended maximum duration of use.

Safety data for Xylometazoline Hydrochloride in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and always under the guidance of a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Both Meralys (Xylometazoline) and oxymetazoline belong to the same class of topical alpha‑adrenergic agonists and share a similar mechanism of action. Xylometazoline may have a slightly longer duration of effect, but individual response varies, and choice often depends on local availability, physician preference, and patient tolerance.

Store Meralys 0,5 Mg/Ml at ambient temperature, preferably below 25 °C. Keep the bottle tightly closed in its original packaging, protect it from moisture and direct sunlight, and avoid freezing. Do not use the product if the solution appears discolored or contains particles.

Meralys is administered as a nasal spray. The user tilts the head slightly forward, inserts the nozzle into one nostril, and sprays the prescribed number of sprays while breathing in gently. The same procedure is repeated in the other nostril if directed by the prescriber.

The most serious risks include rebound nasal congestion after prolonged use, significant increases in blood pressure, and rare cardiovascular events such as arrhythmias. If any severe symptoms such as persistent hypertension, chest pain, or worsening nasal blockage occur, discontinue use and seek medical attention promptly.

Meralys should be avoided in individuals with known hypersensitivity to Xylometazoline or any component of the formulation, in patients with severe hypertension or coronary artery disease unless advised by a physician, and in children younger than six years unless specifically prescribed.

Medically reviewed by

Dr. Shweta Ashok More

M.Pharm (Quality Assurance), Ph.D. (Medicinal Chemistry), GNH India Pharmaceuticals Limited · Reviewed 8 Sep 2026

Published by GNH India Pharmaceuticals Limited · Last updated

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