Product image of MIOSTAT .1 mg/mL (Carbachol) .1 mg/mL SOLUTION supplied by GNH India

MIOSTAT .1 mg/mL

Active Ingredient:
Carbachol
Form:
SOLUTION
Brand:
MIOSTAT
Origin:
USA

MIOSTAT .1 mg/mL (Carbachol SOLUTION) .1 mg/mL

Carbachol, the active ingredient in MIOSTAT, is a muscarinic agonist presented as a 0.1 mg/mL solution for ophthalmic use. It is used to induce miosis during intraocular surgery and to manage certain eye conditions. GNH India supplies MIOSTAT as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

MIOSTAT is a sterile balanced salt solution of carbachol, designed for intraocular injection. It is distributed by Alcon Laboratories, Inc., and is used in specific ophthalmic procedures to achieve the desired therapeutic effects.

Strength

.1 mg/mL

Pack Size

12 VIAL, GLASS in 1 CARTON (0065-0023-15) / 1.5 mL in 1 VIAL, GLASS

Manufacturer / TM Owner

Alcon Laboratories, Inc.

1
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Indications & Clinical Uses

MIOSTAT is a cholinergic agent used in ophthalmic procedures. It is primarily indicated for the following conditions:

  • Intraocular surgery: Induces miosis to facilitate surgical procedures.
  • Glaucoma: Reduces intraocular pressure by increasing the outflow of aqueous humor.
  • Postoperative ocular hypotony: Helps manage intraocular pressure elevation following cataract surgery.

How It Works

  • Carbachol, the active ingredient in MIOSTAT, activates muscarinic receptors in the eye. This action causes contraction of the sphincter pupillae muscle, leading to miosis (constriction of the pupil). Additionally, it increases the outflow of aqueous humor, which helps reduce intraocular pressure.

Side Effects

MIOSTAT may cause various side effects, ranging from common to serious. Common side effects include:

Common Side Effects

  • Headache
  • Irritation or redness of the eyes
  • Blurred vision or changes in near or distance vision
  • Eye pain
  • Stinging or burning of the eye
  • Twitching of the eyelids

Serious or Rare Side Effects

  • Increased intraocular pressure
  • Inflammation of the eye
  • Corneal edema
  • Persistent bullous keratopathy
  • Retinal detachment or postoperative iritis following cataract extraction.

Precautions & Warnings

MIOSTAT should be used with caution in certain conditions. Precautions include:

  • Cardiac conditions: Use with caution in patients with acute cardiac failure.
  • Respiratory conditions: Avoid in patients with bronchial asthma.
  • Gastrointestinal conditions: Use cautiously in patients with peptic ulcers or G.I. spasm.
  • Urinary conditions: Avoid in patients with urinary tract obstruction.
  • Neurological conditions: Use cautiously in patients with Parkinson's disease.
  • Allergies: The vial stopper contains natural rubber (latex), which may cause severe allergic reactions.
  • Storage: Store at 15° - 30°C (59° - 86°F): Keep in the original packaging, protect from moisture and light.

Avoid Interactions

MIOSTAT may interact with other medications, leading to potential adverse effects. Major and moderate interactions include:

Major Interactions (Avoid)

  • Other cholinergic agents: May enhance the effects of carbachol, leading to excessive miosis or other cholinergic effects.
  • Anticholinergic agents: May reduce the effectiveness of carbachol.

Moderate Interactions (Monitor Closely)

  • Beta-blockers: May enhance the intraocular pressure-lowering effects of carbachol.
  • Carbonic anhydrase inhibitors: May enhance the intraocular pressure-lowering effects of carbachol.
  • Prostaglandin analogs: May enhance the intraocular pressure-lowering effects of carbachol.

Frequently Asked Questions

MIOSTAT is used to induce miosis during intraocular surgery and to manage conditions such as glaucoma and postoperative ocular hypotony. It helps reduce intraocular pressure and facilitates surgical procedures by constricting the pupil.

Carbachol, the active ingredient in MIOSTAT, activates muscarinic receptors in the eye. This action causes contraction of the sphincter pupillae muscle, leading to miosis (constriction of the pupil). It also increases the outflow of aqueous humor, which helps reduce intraocular pressure.

The dosage of MIOSTAT is determined by a healthcare professional based on the specific condition being treated. It is typically administered as an intraocular injection during surgery. The exact dose and administration method should be followed as prescribed.

The safety of MIOSTAT during pregnancy or breastfeeding has not been established. It is important to consult with a healthcare provider before using MIOSTAT if you are pregnant, planning to become pregnant, or breastfeeding.

To order MIOSTAT from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will reply with pricing, availability, shipping, and the necessary import paperwork.

MIOSTAT is a specific formulation of carbachol designed for intraocular use. It is particularly effective in inducing miosis during surgery and managing intraocular pressure. Compared to other miotic agents, MIOSTAT's unique formulation and strength make it suitable for specific ophthalmic procedures.

MIOSTAT should be stored at 15° - 30°C (59° - 86°F). Keep it in the original packaging, protect from moisture and light, and ensure the container is undamaged. Follow the storage instructions provided with the product to maintain its effectiveness.

MIOSTAT is administered as an intraocular injection during surgery. A healthcare professional will aseptically remove the sterile vial, withdraw the contents into a sterile syringe, and instill it into the anterior chamber of the eye. The exact administration method should be followed as prescribed.

The most serious risks associated with MIOSTAT include increased intraocular pressure, inflammation of the eye, corneal edema, persistent bullous keratopathy, and retinal detachment or postoperative iritis following cataract extraction. Patients should be monitored for these adverse effects.

MIOSTAT should not be used by patients with acute cardiac failure, bronchial asthma, peptic ulcers, hyperthyroidism, G.I. spasm, urinary tract obstruction, or Parkinson's disease. Additionally, patients with a known allergy to carbachol or any of the inactive ingredients in MIOSTAT should avoid using it.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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