Product image of MOUNJARO 2.5 mg/.5mL (Tirzepatide) 2.5 mg/.5mL INJECTION, SOLUTION supplied by GNH India

MOUNJARO 2.5 mg/.5mL

Active Ingredient:
Tirzepatide
Form:
INJECTION, SOLUTION
Brand:
MOUNJARO
Origin:
USA

MOUNJARO 2.5 mg/.5mL (Tirzepatide INJECTION, SOLUTION) 2.5 mg/.5mL

Tirzepatide, the active ingredient in MOUNJARO 2.5 mg/0.5mL, is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist presented as a 2.5 mg/0.5mL injection, solution for subcutaneous use. It is used as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus.

GNH India supplies MOUNJARO 2.5 mg/0.5mL as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Strength

2.5 mg/.5mL

Pack Size

4 SYRINGE in 1 CARTON (0002-1506-61) / .5 mL in 1 SYRINGE

Manufacturer / TM Owner

Eli Lilly and Company

1
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Indications & Clinical Uses

MOUNJARO 2.5 mg/0.5mL is indicated for the management of type 2 diabetes mellitus and related conditions.

  • Type 2 diabetes mellitus: Improves glycemic control in adults and pediatric patients 10 years of age and older.
  • Cardiovascular risk reduction: Reduces the risk of major adverse cardiovascular events in adults with type 2 diabetes mellitus who are at high risk for these events.
  • Weight management: As an adjunct to a reduced-calorie diet and increased physical activity for weight management in adults with obesity or overweight with at least one weight-related comorbid condition.

How It Works

  • Tirzepatide enhances first- and second-phase insulin secretion and reduces glucagon levels in a glucose-dependent manner. It selectively binds to and activates both the GIP and GLP-1 receptors, which are targets for native GIP and GLP-1. This dual action helps to lower fasting and postprandial glucose concentrations, decrease food intake, and reduce body weight in patients with type 2 diabetes mellitus.

Side Effects

MOUNJARO 2.5 mg/0.5mL may cause various side effects, ranging from common to serious.

Common Side Effects

  • Nausea
  • Diarrhea
  • Decreased appetite
  • Vomiting
  • Constipation
  • Indigestion
  • Abdominal pain

Serious or Rare Side Effects

  • Acute pancreatitis
  • Hypoglycemia when used with insulin secretagogues or insulin
  • Hypersensitivity reactions, including anaphylaxis and angioedema
  • Acute kidney injury due to volume depletion
  • Severe gastrointestinal adverse reactions
  • Diabetic retinopathy complications in patients with a history of diabetic retinopathy
  • Acute gallbladder disease

Precautions & Warnings

MOUNJARO 2.5 mg/0.5mL should be used with caution and certain precautions should be observed.

  • Acute pancreatitis: Discontinue if suspected.
  • Hypoglycemia: Monitor blood glucose levels when used with insulin secretagogues or insulin.
  • Hypersensitivity reactions: Discontinue if suspected and seek medical advice promptly.
  • Acute kidney injury: Monitor renal function in patients reporting adverse reactions that could lead to volume depletion.
  • Severe gastrointestinal adverse reactions: Not recommended in patients with severe gastroparesis.
  • Diabetic retinopathy: Monitor patients with a history of diabetic retinopathy for progression.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

MOUNJARO 2.5 mg/0.5mL may interact with other medications, requiring careful monitoring.

Major Interactions (Avoid)

  • Insulin secretagogues: Increased risk of hypoglycemia.
  • Insulin: Increased risk of hypoglycemia.

Moderate Interactions (Monitor Closely)

  • Oral medications: MOUNJARO delays gastric emptying and may impact the absorption of concomitantly administered oral medications.
  • Other GLP-1 receptor agonists: Potential for additive gastrointestinal side effects.
  • Other medications affecting gastrointestinal motility: Potential for additive gastrointestinal side effects.

Frequently Asked Questions

MOUNJARO 2.5 mg/0.5mL is used as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus. It is also indicated to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes mellitus who are at high risk for these events.

Tirzepatide works by enhancing first- and second-phase insulin secretion and reducing glucagon levels in a glucose-dependent manner. It selectively binds to and activates both the GIP and GLP-1 receptors, which helps to lower fasting and postprandial glucose concentrations, decrease food intake, and reduce body weight in patients with type 2 diabetes mellitus.

The recommended starting dosage of MOUNJARO 2.5 mg/0.5mL is 2.5 mg injected subcutaneously once weekly. The dose can be increased in 2.5 mg increments after at least 4 weeks on the current dose, up to a maximum of 15 mg once weekly for adults and 10 mg once weekly for pediatric patients 10 years of age and older. The prescriber will determine the appropriate dose based on individual patient needs.

The safety of MOUNJARO 2.5 mg/0.5mL during pregnancy or breastfeeding has not been established. It is important to consult with a healthcare provider to discuss the potential risks and benefits before using this medication during pregnancy or while breastfeeding.

To order MOUNJARO 2.5 mg/0.5mL from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will then provide pricing, availability, shipping, and the necessary import paperwork.

MOUNJARO 2.5 mg/0.5mL is a dual GIP and GLP-1 receptor agonist, which distinguishes it from other type 2 diabetes medications that may only target one of these receptors. This dual action can provide additional benefits in glycemic control and weight management compared to single-receptor agonists.

MOUNJARO 2.5 mg/0.5mL should be stored in the refrigerator between 36°F to 46°F (2°C to 8°C). If needed, it can be stored at room temperature up to 86°F (30°C) for up to 21 days. It should be protected from light and not be frozen. Always follow the storage instructions provided in the product packaging.

MOUNJARO 2.5 mg/0.5mL is administered subcutaneously once weekly. It can be injected in the abdomen, thigh, or upper arm. The injection site should be rotated with each dose. The medication can be administered at any time of day, with or without meals.

The most serious risks to watch for with MOUNJARO 2.5 mg/0.5mL include acute pancreatitis, severe hypoglycemia when used with insulin secretagogues or insulin, hypersensitivity reactions, acute kidney injury due to volume depletion, and severe gastrointestinal adverse reactions. Patients should be monitored closely for these potential risks.

MOUNJARO 2.5 mg/0.5mL should not be used by individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2. It is also not recommended for patients with severe gastroparesis. Always consult with a healthcare provider to determine if this medication is appropriate for you.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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