Orkambi 125 mg (Ivacaftor GRANULES) 125 MG

Orkambi 125 mg granules contain ivacaftor, a medication used to treat cystic fibrosis. This oral formulation helps manage symptoms and improve lung function in eligible patients.

Strength

125 MG

Manufacturer / TM Owner

VERTEX PHARMACEUTICALS (CANADA) INCORPORATED

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Indications & Clinical Uses

Orkambi 125 mg granules are primarily used in the management of cystic fibrosis. Ivacaftor, the active ingredient, works to improve the function of a protein affected by the CFTR gene mutation. This medication is often prescribed as part of a comprehensive treatment plan to help manage symptoms and enhance lung function in individuals with specific genetic markers.

Side Effects

Common effects of Orkambi 125 mg granules may include gastrointestinal discomfort, such as abdominal pain or diarrhea. Some users may also experience headaches or dizziness. These effects vary among individuals and are not experienced by everyone taking the medication.

Precautions & Warnings

Orkambi 125 mg granules should be handled with care, ensuring proper storage and administration as directed. It is important to follow the prescribed dosage and consult a healthcare provider before starting or stopping the medication. Always inform your healthcare provider about any other medications you are taking to avoid potential interactions.

Avoid Interactions

Orkambi 125 mg granules may interact with certain medications, including those metabolized by the liver's CYP3A4 enzyme. It is advisable to avoid grapefruit and grapefruit juice, as they can affect the metabolism of ivacaftor. Always consult a healthcare provider before combining Orkambi with other medications.

Frequently Asked Questions

Orkambi 125 mg granules are used to manage cystic fibrosis in patients with specific genetic markers. The medication helps improve the function of a protein affected by the CFTR gene mutation.

Orkambi 125 mg granules are taken orally, typically mixed with a small amount of soft food or liquid. The exact administration method should be discussed with a healthcare provider.

Common side effects may include gastrointestinal discomfort, headaches, and dizziness. These effects vary among individuals and are not experienced by everyone taking the medication.

Orkambi 125 mg may interact with certain medications, particularly those metabolized by the liver's CYP3A4 enzyme. It is important to consult a healthcare provider before combining Orkambi with other medications.

Orkambi 125 mg is specifically indicated for patients with cystic fibrosis who have certain genetic markers. It is not suitable for all cystic fibrosis patients, and a healthcare provider should determine eligibility.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 29 Jul 2026

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