PredniSONE 20 mg/1 (PredniSONE TABLET) 20 mg/1

PredniSONE is a glucocorticoid used to treat a variety of inflammatory and autoimmune conditions. It works by reducing inflammation and modifying the body's immune response.

• Inflammatory disorders: Reduces inflammation in conditions such as arthritis and asthma.
• Autoimmune diseases: Suppresses the immune system in diseases like lupus and rheumatoid arthritis.
• Allergic reactions: Alleviates symptoms of severe allergic reactions.
• Asthma: Reduces inflammation in the airways to improve breathing.
• Rheumatoid arthritis: Decreases joint inflammation and pain.
• Dermatologic conditions: Treats skin conditions like psoriasis and dermatitis.

• Prednisone works by binding to intracellular glucocorticoid receptors, which then regulate the transcription of anti-inflammatory and immunosuppressive genes. This leads to a decrease in the production of inflammatory cytokines and other mediators, reducing inflammation and modifying the immune response.

Prednisone can cause a range of side effects, some of which are common and others that are serious or rare.

Common Side Effects

• Increased appetite
• Weight gain
• Mood changes
• Difficulty sleeping
• Increased sweating
• Acne
• Facial swelling
• High blood pressure
• Muscle weakness

Serious or Rare Side Effects

• Severe allergic reactions
• Changes in emotions or moods, such as depression
• Changes in vision
• Eye pain
• Infection symptoms, such as fever, chills, or sore throat
• High blood sugar symptoms, such as increased thirst or urinating more often
• Swelling of the ankles or feet

Prednisone should be used with caution and under the supervision of a healthcare provider. It is important to follow the prescribed dosage and monitor for any adverse effects.

• Avoid in whole-body fungal infections: Do not use prednisone oral tablets or liquid for people with fungal infections in their body.
• Immune system effects: Prednisone may reduce immune system activity, increasing the risk of infections.
• Bone health: Long-term use can lead to osteoporosis and bone fractures.
• Eye health: Prolonged use can increase the risk of cataracts and glaucoma.
• Diabetes: Prednisone can increase blood sugar levels, requiring monitoring in diabetic patients.
• Store below 25°C: Keep in the original pack, protect from moisture.

Prednisone can interact with other medications, which may affect its efficacy or increase the risk of side effects.

Major Interactions (Avoid)

• Live vaccines: Avoid concurrent use with live vaccines due to the risk of infection.
• Nonsteroidal anti-inflammatory drugs (NSAIDs): Increased risk of gastrointestinal bleeding.
• Anticoagulants: Increased risk of bleeding.
• Diuretics: Increased risk of hypokalemia.
• Antidiabetic drugs: May require adjustment of antidiabetic therapy.

Moderate Interactions (Monitor Closely)

• Antiepileptic drugs: May decrease the effectiveness of prednisone.
• Estrogens: May increase the metabolism of prednisone.
• Anticholinesterases: May increase the risk of muscle weakness.
• Antithyroid drugs: May require adjustment of thyroid therapy.