Product image of Quinine Sulphate 200mg (Quinine Sulphate) 200mg Tablet supplied by GNH India

Quinine Sulphate 200mg

Active Ingredient:
Quinine Sulphate
Form:
Tablet
Brand:
Quinine Sulphate
Origin:
UK

Quinine Sulphate 200mg (Quinine Sulphate Tablet) 200mg

Quinine sulfate, the active ingredient in Quinine Sulphate 200mg, is a quinoline antimalarial presented as a 200mg tablet for oral use. It is used to treat uncomplicated malaria caused by Plasmodium falciparum and, off-label, for nocturnal leg cramps. GNH India supplies Quinine Sulphate 200mg as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Quinine sulfate is a well-established medication with a dual role in treating malaria and managing nocturnal leg cramps. Its efficacy and safety profile make it a valuable option in both indications.

Strength

200mg

Pack Size

28s

Storage

Ambient

Manufacturer / TM Owner

Accord

1
Pack/s
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Indications & Clinical Uses

Quinine sulfate is primarily used to treat malaria and, off-label, for nocturnal leg cramps.

  • Uncomplicated malaria (Plasmodium falciparum): Treats malaria caused by Plasmodium falciparum.
  • Nocturnal leg cramps: Reduces the frequency and severity of leg cramps that disrupt sleep.

How It Works

  • Quinine sulfate interferes with haem polymerisation in Plasmodium parasites, leading to toxic haem accumulation. This mechanism disrupts the parasite's ability to survive and replicate within red blood cells, effectively treating malaria infections.

Side Effects

Quinine sulfate can cause various side effects, ranging from common to serious.

Common Side Effects

  • Tinnitus
  • Impaired hearing
  • Headache
  • Nausea
  • Disturbed vision
  • Confusion
  • Flushing
  • Abdominal pain

Serious or Rare Side Effects

  • Thrombocytopenia
  • Hemolytic uremic syndrome/thrombotic thrombocytopenic purpura (HUS/TTP)
  • Chronic renal impairment
  • Severe visual loss
  • Fatalities in overdose

Precautions & Warnings

Quinine sulfate should be used with caution and under medical supervision.

  • Prescription: Only use as prescribed by a healthcare professional.
  • Allergies: Avoid if allergic to quinine or any of the ingredients.
  • Monitoring: Regular monitoring is required during treatment.
  • Discontinuation: Treatment should be interrupted every 3 months to reassess benefits.
  • Storage: Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Quinine sulfate can interact with other medications, potentially affecting its efficacy or increasing the risk of side effects.

Major Interactions (Avoid)

  • Digoxin: Can increase the risk of digoxin toxicity.
  • Warfarin: Can enhance the anticoagulant effect, increasing bleeding risk.

Moderate Interactions (Monitor Closely)

  • Antidiabetic drugs: May affect blood sugar control.
  • Antihypertensive drugs: May affect blood pressure control.
  • Other medications metabolized by CYP3A4: May alter quinine sulfate metabolism.

Frequently Asked Questions

Quinine Sulphate 200mg is primarily used to treat uncomplicated malaria caused by Plasmodium falciparum. It is also used off-label to reduce the frequency and severity of nocturnal leg cramps that disrupt sleep.

Quinine sulfate works by interfering with haem polymerisation in Plasmodium parasites, leading to toxic haem accumulation. This disrupts the parasite's ability to survive and replicate within red blood cells, effectively treating malaria infections.

The usual dose of Quinine Sulphate 200mg is one tablet at bedtime. The prescriber sets the exact dosage and duration based on the patient's condition and response to treatment.

The safety of Quinine Sulphate 200mg during pregnancy or breastfeeding has not been established. It should be used only if clearly needed and under medical supervision.

To order Quinine Sulphate 200mg from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will reply with pricing, availability, shipping, and the import paperwork.

Quinine Sulphate 200mg is an older antimalarial drug that is effective against Plasmodium falciparum. It is often compared to newer antimalarials like artemisinin-based combination therapies (ACTs), which are generally preferred due to their better safety profile and efficacy.

Quinine Sulphate 200mg should be stored below 25°C, in the original pack, and protected from moisture. Keep all medicines out of the reach and sight of children.

Quinine Sulphate 200mg is administered orally, typically as one tablet at bedtime. The tablet should be swallowed with a drink of water.

The most serious risks associated with Quinine Sulphate 200mg include thrombocytopenia, hemolytic uremic syndrome/thrombotic thrombocytopenic purpura (HUS/TTP), chronic renal impairment, severe visual loss, and fatalities in overdose. Patients should be monitored closely for these risks.

Quinine Sulphate 200mg should not be used by individuals who are allergic to quinine or any of the ingredients. It should also be avoided in patients with a history of thrombocytopenia or other serious adverse reactions to quinine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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