Sildenafil 100 mg (Sildenafil (Sildenafil Citrate) TABLET) 100 MG

Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor used to treat conditions related to blood flow and vascular health.

• Erectile dysfunction: Helps achieve and maintain an erection sufficient for sexual activity.
• Pulmonary arterial hypertension: Improves exercise capacity and symptoms in patients with this condition.

• Sildenafil works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which leads to increased levels of cyclic guanosine monophosphate (cGMP). This causes relaxation of smooth muscle in blood vessels, allowing improved blood flow. This mechanism is central to how Sildenafil functions pharmacologically, particularly in the corpus cavernosum and pulmonary vasculature.

Sildenafil may cause various side effects, ranging from common to serious or rare.

Common Side Effects

• Headache
• Flushing
• Indigestion
• Nasal congestion
• Dizziness
• Vision changes, including blurred vision or sensitivity to light
• Nausea
• Muscle aches

Serious or Rare Side Effects

• Prolonged erection (priapism)
• Sudden vision loss or hearing loss
• Severe allergic reactions, including rash, itching, or swelling
• Chest pain or irregular heartbeat
• Fainting or dizziness, which may indicate a severe drop in blood pressure
• Seizures
• Signs of bleeding from the lungs, such as difficulty breathing or bluish coloring of the lips

Sildenafil should be used with caution and under the supervision of a healthcare professional. Important precautions include:

• Nitrate medications: Avoid taking Sildenafil with any nitrate-containing medications, as it can cause a severe drop in blood pressure.
• Cardiovascular conditions: Use with caution in patients with heart conditions, as sexual activity can increase the risk of heart-related side effects.
• Low blood pressure: Monitor blood pressure closely, especially when starting treatment.
• Liver or kidney disease: Dose adjustments may be necessary for patients with liver or kidney impairment.
• Store below 25°C: Keep in the original pack, protect from moisture.

Sildenafil can interact with other medications, which may affect its efficacy or increase the risk of side effects.

Major Interactions (Avoid)

• Nitrates: Concurrent use can cause a severe drop in blood pressure, leading to dizziness, fainting, heart attack, or stroke.
• Riociguat: Concurrent use can cause a severe drop in blood pressure.
• Alpha-blockers: May increase the risk of hypotension.
• HIV protease inhibitors: Can increase sildenafil levels, leading to an increased risk of side effects.
• Certain antifungal medications: Can increase sildenafil levels, leading to an increased risk of side effects.

Moderate Interactions (Monitor Closely)

• Blood pressure medications: May enhance the blood pressure-lowering effects of sildenafil.
• Erythromycin: Can increase sildenafil levels, leading to an increased risk of side effects.
• Other PDE5 inhibitors: Concurrent use may increase the risk of side effects.