Trazodone Hydrochloride 100 mg/1 (Trazodone Hydrochloride TABLET) 100 mg/1

Trazodone Hydrochloride is an antidepressant used to manage mood disorders by acting on the serotonergic pathway.

• Major depressive disorder: Improves symptoms of depression such as low mood, fatigue, and loss of interest.
• Insomnia (off-label): May help improve sleep quality in some patients.
• Anxiety disorders (off-label): Can reduce symptoms of anxiety in certain cases.

• Trazodone Hydrochloride works by antagonizing 5-HT2A receptors and weakly inhibiting serotonin reuptake, which results in increased serotonergic neurotransmission. This dual action helps to regulate mood and alleviate symptoms of depression.

Trazodone Hydrochloride may cause various side effects, ranging from mild to severe.

Common Side Effects

• Headache
• Drowsiness or sedation
• Dry mouth
• Dizziness
• Nausea
• Fatigue
• Diarrhea
• Constipation
• Blurred vision

Serious or Rare Side Effects

• Back pain
• Severe dizziness or light-headedness
• Severe nausea or vomiting
• Unusual bleeding or bruising
• Signs of an allergic reaction, such as rash, itching, or swelling

Trazodone Hydrochloride should be used with caution and under medical supervision. Important precautions include:

• Pregnancy: Should be used with caution, as it falls under pregnancy category C, indicating potential risks to the fetus.
• Breastfeeding: Should be used with caution, as it may pass into breast milk.
• Driving or operating machinery: May cause drowsiness, affecting alertness.
• Alcohol consumption: Should be avoided, as it can enhance the sedative effects.
• Medical history: Should be discussed with a healthcare provider, especially if there is a history of heart disease, liver disease, or bipolar disorder.
• Store below 25°C: Keep in the original pack, protect from moisture and light.

Trazodone Hydrochloride can interact with other medications, potentially altering its effectiveness or increasing the risk of side effects.

Major Interactions (Avoid)

• MAO inhibitors: Can cause serious and potentially fatal interactions, including serotonin syndrome.
• CYP3A4 inhibitors: Can increase the concentration of trazodone in the blood, leading to increased side effects.
• Triptans: Can increase the risk of serotonin syndrome.

Moderate Interactions (Monitor Closely)

• Anticoagulants: May increase the risk of bleeding.
• Antihypertensives: May enhance the hypotensive effects, leading to dizziness or fainting.
• Benzodiazepines: May enhance the sedative effects, leading to excessive drowsiness.