Up and Up Naproxen Sodium Pm 220 mg/1 (Diphenhydramine Hydrochloride, Naproxen Sodium TABLET, FILM COATED) 220 mg/1

Up and Up Naproxen Sodium PM 220 mg combines naproxen sodium and diphenhydramine hydrochloride for pain relief and sleep support. This oral tablet is designed to help manage discomfort while promoting restful sleep.

Strength

220 mg/1

Pack Size

1 BOTTLE in 1 CARTON (11673-687-27) / 80 TABLET, FILM COATED in 1 BOTTLE

Manufacturer / TM Owner

Target Corporation

Select Quantity

Pack/s

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Indications & Clinical Uses

Up and Up Naproxen Sodium PM 220 mg is commonly used for pain relief and to aid sleep. The combination of naproxen sodium, a nonsteroidal anti-inflammatory drug (NSAID), and diphenhydramine hydrochloride, an antihistamine, makes it suitable for addressing minor aches and promoting relaxation. People often seek this medication when they need relief from discomfort and want to improve sleep quality.

Side Effects

When taken as directed, Up and Up Naproxen Sodium PM 220 mg may help reduce pain and inflammation, making it easier to fall asleep. Some users report feeling drowsy due to the presence of diphenhydramine hydrochloride, which is intended to support sleep. Individual responses can vary.

Precautions & Warnings

It's important to handle Up and Up Naproxen Sodium PM 220 mg with care. Always follow the instructions provided with the medication. Avoid operating heavy machinery or driving after taking this medication, as it may cause drowsiness. Consult a healthcare provider before use if you have any underlying health conditions or are taking other medications.

Avoid Interactions

Up and Up Naproxen Sodium PM 220 mg may interact with other medications, including other NSAIDs, antihistamines, and certain pain relievers. Alcohol and other sedatives can enhance the drowsiness caused by diphenhydramine hydrochloride. Always inform your healthcare provider about all medications you are taking to avoid potential interactions.

Frequently Asked Questions

Up and Up Naproxen Sodium PM 220 mg is used for pain relief and to aid sleep. It combines naproxen sodium for pain and inflammation and diphenhydramine hydrochloride for sleep support.

Follow the instructions on the packaging or as directed by your healthcare provider. Typically, it is taken orally with water.

Yes, the diphenhydramine hydrochloride in Up and Up Naproxen Sodium PM 220 mg is intended to cause drowsiness to aid sleep.

Avoid alcohol and operating heavy machinery or driving, as the medication can cause drowsiness.

Consult a healthcare provider before use, especially if you have underlying health conditions or are taking other medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 29 Jul 2026

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