Product image of ZEPBOUND 2.5mg/0.5ml (Tirzepatide) 2.5mg/0.5ml Vials supplied by GNH India

ZEPBOUND 2.5mg/0.5ml

Active Ingredient:
Tirzepatide
Form:
Vials
Brand:
ZEPBOUND
Origin:
USA

ZEPBOUND 2.5mg/0.5ml (Tirzepatide Vials) 2.5mg/0.5ml

Tirzepatide, the active ingredient in Zepbound, is a GIP/GLP-1 receptor agonist presented as a 2.5mg/0.5ml vial for subcutaneous use. It is used for chronic weight management in adults with obesity or overweight with weight-related medical problems, and to improve obstructive sleep apnea (OSA) in adults with obesity. GNH India supplies Zepbound as a licensed, GDP-compliant international pharmaceutical supplier serving pharmacies and clinics worldwide.

Zepbound is an injectable prescription medication designed to help adults manage their weight in conjunction with a reduced-calorie diet and increased physical activity. It is available in various strengths and forms, including pre-filled pens and vials, to accommodate different patient needs.

Strength

2.5mg/0.5ml

Pack Size

4s

Storage

2-8°

Manufacturer / TM Owner

LILLY ELI & CO

1
Pack/s
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Indications & Clinical Uses

Zepbound is a GIP/GLP-1 receptor agonist used in the management of obesity and related conditions. It is indicated for:

  • Obesity: To help adults with obesity lose excess body weight and keep the weight off.
  • Overweight with weight-related medical problems: To assist in weight management for adults who are overweight and have conditions such as type 2 diabetes or moderate-to-severe obstructive sleep apnea (OSA).
  • Obstructive sleep apnea (OSA): To improve OSA in adults with obesity.

How It Works

  • Tirzepatide, the active ingredient in Zepbound, works by activating both the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. This dual action enhances insulin secretion, suppresses glucagon release, slows gastric emptying, and reduces appetite, leading to weight loss and improved metabolic control.

Side Effects

Zepbound may cause various side effects, ranging from common to serious or rare. Common Side Effects:

  • Nausea
  • Diarrhea
  • Decreased appetite
  • Vomiting
  • Constipation
  • Injection site reactions

Serious or Rare Side Effects

  • Tumors in the thyroid, including thyroid cancer
  • Pancreatitis
  • Hypoglycemia (low blood sugar)
  • Gallbladder problems
  • Kidney problems
  • Allergic reactions
  • Changes in vision

Precautions & Warnings

Zepbound should be used with caution and under the supervision of a healthcare provider. Important precautions include:

  • Do not use if you have a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • Do not use if you have had a serious allergic reaction to tirzepatide or any of its ingredients.
  • Monitor for symptoms of thyroid tumors, such as a lump or swelling in the neck, hoarseness, or trouble swallowing.
  • Be aware of the risk of hypoglycemia, especially when used with other diabetes medications.
  • Inform your healthcare provider about all other medications you are taking to avoid potential interactions.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Zepbound may interact with other medications, which can affect its efficacy or increase the risk of side effects. Major Interactions (Avoid):

  • Other tirzepatide-containing products
  • GLP-1 receptor agonist medicines

Moderate Interactions (Monitor Closely)

  • Insulin or other diabetes medications, as they may increase the risk of hypoglycemia.
  • Medications that affect stomach emptying, as they may alter the absorption of Zepbound.
  • Medications metabolized by the liver, as Zepbound may affect their metabolism.

Frequently Asked Questions

Zepbound is used for chronic weight management in adults with obesity or overweight with weight-related medical problems. It is also used to improve obstructive sleep apnea (OSA) in adults with obesity. The medication works by activating both GIP and GLP-1 receptors, which helps in reducing appetite and promoting weight loss.

Tirzepatide, the active ingredient in Zepbound, works by activating both the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. This dual action enhances insulin secretion, suppresses glucagon release, slows gastric emptying, and reduces appetite, leading to weight loss and improved metabolic control.

The usual starting dose of Zepbound is 2.5mg once weekly, which may be increased gradually under the supervision of a healthcare provider. The maximum recommended dose is 15mg once weekly. The prescriber will determine the appropriate dose based on individual patient needs and response to treatment.

The safety of Zepbound during pregnancy or breastfeeding has not been established. It is important to consult with a healthcare provider before using Zepbound if you are pregnant, planning to become pregnant, or breastfeeding. The prescriber will weigh the potential benefits against the risks to determine the best course of action.

To order Zepbound from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will then provide pricing, availability, shipping (including cold-chain where relevant), and the necessary import paperwork.

Zepbound is unique in that it is a dual GIP/GLP-1 receptor agonist, which is different from other weight loss medications that may only target one of these receptors. This dual action can provide a more comprehensive approach to weight management. However, the choice of medication depends on individual patient needs and should be discussed with a healthcare provider.

Zepbound should be stored in the refrigerator between 36°F to 46°F (2°C to 8°C). It can be stored at room temperature up to 86°F (30°C) for up to 21 days. Once removed from the refrigerator, do not return it to the fridge. Never freeze Zepbound and always protect it from light by storing it in the original carton.

Zepbound is administered as a subcutaneous injection once weekly. It comes in pre-filled pens or vials, and the injection can be given at any time of the day. Patients or caregivers should be properly trained on how to administer the injection to ensure safety and effectiveness.

The most serious risks associated with Zepbound include tumors in the thyroid, including thyroid cancer, pancreatitis, hypoglycemia, gallbladder problems, kidney problems, and allergic reactions. Patients should be monitored for symptoms such as a lump or swelling in the neck, severe abdominal pain, signs of low blood sugar, and allergic reactions, and should report these to their healthcare provider immediately.

Zepbound should not be used by individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). It should also not be used by those who have had a serious allergic reaction to tirzepatide or any of its ingredients. Patients should consult with their healthcare provider to determine if Zepbound is suitable for them.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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