Product image of Zoledronic Acid 4 mg/5mL (Zoledronic Acid) 4 mg/5mL INJECTION, SOLUTION, CONCENTRATE supplied by GNH India

Zoledronic Acid 4 mg/5mL

Active Ingredient:
Zoledronic Acid
Form:
INJECTION, SOLUTION, CONCENTRATE
Brand:
Zoledronic Acid
Origin:
USA

Zoledronic Acid 4 mg/5mL (Zoledronic Acid INJECTION, SOLUTION, CONCENTRATE) 4 mg/5mL

Zoledronic acid, the active ingredient in Zoledronic Acid 4 mg/5mL, is a bisphosphonate presented as a 4 mg/5mL injection, solution, concentrate for intravenous use. It is used to treat conditions such as high blood calcium levels (hypercalcemia) associated with cancer, bone problems in multiple myeloma and other cancers that have spread to the bones, and to prevent bone fractures. GNH India supplies Zoledronic Acid 4 mg/5mL as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

GNH India is a trusted supplier of high-quality pharmaceuticals, ensuring that Zoledronic Acid 4 mg/5mL meets international standards and regulatory requirements.

Strength

4 mg/5mL

Pack Size

5 mL in 1 VIAL (0143-9642-01)

Manufacturer / TM Owner

Hikma Pharmaceuticals USA Inc.

1
Pack/s
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Indications & Clinical Uses

Zoledronic Acid 4 mg/5mL is a bisphosphonate used to manage bone-related conditions and complications. It is primarily indicated for the following:

  • Hypercalcemia of malignancy: Reduces high blood calcium levels caused by tumors.
  • Bone metastases: Prevents skeletal-related events such as fractures in patients with bone metastases from various cancers.
  • Multiple myeloma: Treats bone complications associated with this type of cancer.
  • Paget's disease of bone: Helps manage this chronic bone disorder.

How It Works

  • Zoledronic acid works by inhibiting osteoclast-mediated bone resorption. It binds to hydroxyapatite in bone tissue and induces osteoclast apoptosis, thereby slowing down the breakdown of bone. This action helps to lower blood calcium levels and reduce bone pain and fractures associated with various bone conditions.

Side Effects

Zoledronic Acid 4 mg/5mL may cause several side effects, ranging from common to serious or rare.

Common Side Effects

  • Fever
  • Fatigue
  • Nausea
  • Bone pain
  • Headache
  • Constipation
  • Dizziness
  • Joint pain

Serious or Rare Side Effects

  • Osteonecrosis of the jaw: Severe jawbone problems, including poor healing and exposed bone.
  • Kidney problems: Changes in kidney function, including reduced urine output and lower back pain.
  • Low blood calcium levels: Symptoms include muscle spasms, tingling, and numbness.
  • Severe bone, joint, or muscle pain: May occur after the infusion.
  • Allergic reactions: Symptoms include rash, itching, and difficulty breathing.

Precautions & Warnings

Zoledronic Acid 4 mg/5mL should be used with caution and under the supervision of a healthcare professional. Important precautions include:

  • Kidney function: Monitor kidney function before and during treatment, as zoledronic acid can affect kidney function.
  • Jaw health: Regular dental check-ups are recommended to prevent osteonecrosis of the jaw.
  • Calcium levels: Monitor blood calcium levels regularly, especially in patients with hypercalcemia.
  • Pregnancy: Avoid use during pregnancy due to potential harm to the fetus.
  • Breastfeeding: Avoid use during breastfeeding, as the effects on the infant are not well understood.
  • Allergies: Inform your doctor if you have any known allergies to bisphosphonates or any other medications.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Zoledronic Acid 4 mg/5mL may interact with other medications, which can affect its efficacy and safety. Important interactions include:

Major Interactions (Avoid)

  • Other bisphosphonates: Avoid concurrent use to prevent additive side effects.
  • Calcium-containing products: Avoid mixing with solutions containing calcium ions, such as lactated Ringer's solution.
  • Aminoglycosides: Avoid concurrent use due to increased risk of kidney damage.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: Monitor kidney function closely, as these medications can increase the risk of kidney damage.
  • NSAIDs: Monitor for signs of kidney damage and gastrointestinal issues.
  • Other nephrotoxic drugs: Monitor kidney function regularly to prevent additive kidney damage.

Frequently Asked Questions

Zoledronic Acid 4 mg/5mL is used to treat high blood calcium levels (hypercalcemia) associated with cancer, prevent bone complications in patients with bone metastases, and manage bone problems in multiple myeloma and Paget's disease of bone. It works by slowing down the breakdown of bone tissue, thereby reducing bone pain and preventing fractures.

Zoledronic Acid works by inhibiting osteoclast-mediated bone resorption. It binds to hydroxyapatite in bone tissue and induces osteoclast apoptosis, which helps to lower blood calcium levels and reduce bone pain and fractures. This action is crucial in managing conditions like hypercalcemia and bone metastases.

The dosage of Zoledronic Acid 4 mg/5mL is determined by a healthcare professional based on the patient's medical condition and response to treatment. It is typically administered as a single intravenous infusion over at least 15 minutes. The specific dosage and frequency will be tailored to the individual patient's needs.

Zoledronic Acid is not recommended for use during pregnancy or breastfeeding. It is classified as a pregnancy category X drug, meaning it should be avoided during pregnancy due to potential harm to the fetus. The effects on infants during breastfeeding are not well understood, so it is best to avoid use during this period.

To order Zoledronic Acid 4 mg/5mL from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will then provide pricing, availability, shipping (including cold-chain where relevant), and the necessary import paperwork.

Zoledronic Acid is a potent bisphosphonate with a longer duration of action compared to other bisphosphonates like pamidronate. It is often preferred for its convenience and efficacy in managing bone-related complications. However, the choice of bisphosphonate depends on the specific condition being treated and the patient's individual needs.

Zoledronic Acid 4 mg/5mL should be stored at 2-8°C, refrigerated, and protected from light. It should not be frozen or shaken. Proper storage is essential to maintain the medication's efficacy and safety. Always follow the storage instructions provided by the manufacturer and healthcare professional.

Zoledronic Acid 4 mg/5mL is administered as an intravenous infusion over at least 15 minutes. It should be given by healthcare professionals experienced in the administration of intravenous bisphosphonates. The infusion should be administered as a single dose using a separate system and should not be mixed with solutions containing calcium ions.

The most serious risks associated with Zoledronic Acid 4 mg/5mL include osteonecrosis of the jaw, kidney problems, and severe bone, joint, or muscle pain. Patients should be monitored for these risks, and any symptoms should be reported to a healthcare professional immediately. Regular dental check-ups and monitoring of kidney function are recommended.

Zoledronic Acid 4 mg/5mL should not be used by individuals with known hypersensitivity to zoledronic acid or any other bisphosphonates. It is also not recommended for use during pregnancy or breastfeeding. Patients with severe kidney impairment should use it with caution and under the supervision of a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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