Product image of Zortress .75 mg/1 (Everolimus) .75 mg/1 TABLET supplied by GNH India

Zortress .75 mg/1

Active Ingredient:
Everolimus
Form:
TABLET
Brand:
Zortress
Origin:
USA

Zortress .75 mg/1 (Everolimus TABLET) .75 mg/1

Everolimus, the active ingredient in Zortress, is a mTOR inhibitor presented as a 0.75 mg tablet for oral use. It is used to prevent organ rejection in kidney or liver transplant recipients. GNH India supplies Zortress as a licensed, GDP-compliant international pharmaceutical supplier serving transplant centres worldwide.

Zortress is a critical medication for patients who have undergone organ transplants, helping to ensure the body does not reject the new organ. It is part of a broader regimen that includes other immunosuppressants to manage the body's immune response.

Strength

.75 mg/1

Pack Size

60 BLISTER PACK in 1 BOX (0078-0415-20) / 1 TABLET in 1 BLISTER PACK (0078-0415-61)

Manufacturer / TM Owner

Novartis Pharmaceuticals Corporation

1
Pack/s
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Indications & Clinical Uses

Zortress is an immunosuppressant used to prevent organ rejection in transplant patients. It is particularly effective in the following conditions:

  • Kidney Transplant: Prevents rejection of the transplanted kidney by suppressing the immune system's response.
  • Liver Transplant: Helps prevent rejection of the transplanted liver when used in combination with other immunosuppressants.
  • Organ Rejection Prophylaxis: Used in combination with cyclosporine, steroids, and other medications to prevent the body from attacking the transplanted organ.

How It Works

  • Everolimus works by inhibiting the mammalian target of rapamycin (mTOR) pathway, which plays a key role in cell proliferation, growth, and survival. By binding to the FKBP-12 protein, everolimus forms a complex that inhibits mTOR, thereby suppressing T-cell proliferation and cytokine production, which helps prevent organ rejection.

Side Effects

Zortress, like all medications, can cause side effects. Common side effects include:

Common Side Effects

  • Fatigue: Feeling unusually tired or weak.
  • Headache: Mild to moderate pain in the head.
  • Nausea: Feeling sick to the stomach.
  • Diarrhea: Loose or watery stools.
  • Swelling: Fluid retention in the body.
  • Increased cholesterol: Elevated levels of cholesterol in the blood.

Serious or Rare Side Effects

  • Infection: Increased risk of infections due to a weakened immune system.
  • Wound healing problems: Delayed healing of surgical wounds.
  • Lung problems: Potential for lung inflammation or other respiratory issues.
  • Kidney problems: Potential for kidney dysfunction or failure.
  • Blood clots: Increased risk of blood clots in the legs or lungs.

Precautions & Warnings

Zortress should be used with caution and under the supervision of a healthcare professional. Important precautions include:

  • Regular Monitoring: Regular blood tests to monitor kidney function and drug levels.
  • Infection Risk: Increased susceptibility to infections; avoid contact with sick individuals.
  • Wound Care: Proper care of surgical wounds to prevent complications.
  • Pregnancy: Should be avoided during pregnancy due to potential risks to the fetus.
  • Breastfeeding: Not recommended due to potential risks to the infant.
  • Storage: Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Zortress can interact with other medications, which may affect its efficacy or increase the risk of side effects. Major and moderate interactions include:

Major Interactions (Avoid)

  • Strong CYP3A4 Inhibitors: Drugs like ketoconazole or ritonavir can increase everolimus levels, leading to toxicity.
  • Strong CYP3A4 Inducers: Drugs like rifampin or phenytoin can decrease everolimus levels, reducing its effectiveness.
  • Live Vaccines: Avoid live vaccines due to increased risk of infection.

Moderate Interactions (Monitor Closely)

  • Immunosuppressants: Other immunosuppressants may increase the risk of infections or other side effects.
  • Antifungals: Some antifungals may interact with everolimus, requiring dose adjustments.
  • Antibiotics: Certain antibiotics may affect everolimus levels, requiring close monitoring.

Frequently Asked Questions

Zortress is used to prevent organ rejection in patients who have undergone kidney or liver transplants. It works by suppressing the immune system's response to the transplanted organ, helping to ensure the body does not reject it. Zortress is typically used in combination with other immunosuppressants to manage the body's immune response effectively.

Everolimus, the active ingredient in Zortress, works by inhibiting the mammalian target of rapamycin (mTOR) pathway. This pathway plays a crucial role in cell proliferation, growth, and survival. By binding to the FKBP-12 protein, everolimus forms a complex that inhibits mTOR, thereby suppressing T-cell proliferation and cytokine production, which helps prevent organ rejection.

The usual dose of Zortress is determined by a healthcare professional based on the patient's specific needs and medical history. For kidney transplant patients, an initial dose of 0.75 mg orally twice daily is recommended in combination with reduced doses of cyclosporine. For liver transplant patients, an initial dose of 1 mg orally twice daily is recommended in combination with reduced doses of tacrolimus. Dose adjustments may be necessary based on blood concentrations and individual response.

Zortress should be avoided during pregnancy due to potential risks to the fetus. It is also not recommended during breastfeeding due to potential risks to the infant. Patients should discuss their reproductive health and contraceptive options with their healthcare provider before starting Zortress.

To order Zortress from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will then reply with pricing, availability, shipping, and the import paperwork.

Zortress is an mTOR inhibitor, which differs from other immunosuppressants like calcineurin inhibitors (e.g., tacrolimus) and corticosteroids. It is specifically used to prevent organ rejection in transplant patients and is often used in combination with other immunosuppressants. The choice of immunosuppressant depends on the patient's specific needs and medical history, as determined by a healthcare professional.

Zortress should be stored below 25°C, keeping it in the original pack and protecting it from moisture. It is important to follow the storage instructions provided with the medication to ensure its effectiveness and safety. Patients should also handle the medication carefully and follow their healthcare provider's instructions for administration.

Zortress is administered orally in the form of tablets. The dosage and administration schedule are determined by a healthcare professional based on the patient's specific needs and medical history. It is important to follow the prescribed dosage and administration instructions to ensure the medication's effectiveness and safety.

The most serious risks associated with Zortress include an increased risk of infections, wound healing problems, lung problems, kidney problems, and blood clots. Patients should be monitored regularly by their healthcare provider and report any unusual symptoms or side effects immediately. It is important to follow the healthcare provider's instructions for monitoring and managing these risks.

Zortress should not be used by patients who are allergic to everolimus or any of the other ingredients in the medication. It should also be avoided during pregnancy and breastfeeding due to potential risks to the fetus and infant. Patients with certain medical conditions, such as severe liver or kidney problems, may also need to avoid Zortress. It is important to discuss any medical conditions and allergies with a healthcare provider before starting Zortress.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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