Product image of Zoryve 0.15 % (Roflumilast) 0.15 % CREAM supplied by GNH India

Zoryve 0.15 %

Active Ingredient:
Roflumilast
Form:
CREAM
Brand:
ZORYVE
Origin:
CANADA

Zoryve 0.15 % (Roflumilast CREAM) 0.15 %

Roflumilast, the active ingredient in Zoryve 0.15%, is a phosphodiesterase-4 (PDE4) inhibitor presented as a 0.15% cream for topical use. It is indicated for the treatment of mild to moderate atopic dermatitis in patients aged 6 years and older.

GNH India supplies Zoryve 0.15% as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Strength

0.15 %

Manufacturer / TM Owner

ARCUTIS CANADA, INC.

1
Pack/s
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Indications & Clinical Uses

Zoryve 0.15% is a topical medication used to manage inflammatory skin conditions.

  • Atopic dermatitis: Reduces inflammation, redness, and itching associated with this chronic skin condition.
  • Plaque psoriasis: Helps alleviate symptoms such as itchy, painful rashes and red patches of skin.
  • Seborrheic dermatitis: Treats flaky, scaly, and greasy skin on the scalp, face, chest, or other oily body areas.

How It Works

  • Roflumilast works by inhibiting phosphodiesterase-4 (PDE4), an enzyme that metabolizes cyclic AMP. This inhibition leads to an accumulation of intracellular cyclic AMP, which reduces the production of inflammatory cytokines, thereby decreasing inflammation in the skin.

Side Effects

Zoryve 0.15% may cause various side effects, ranging from common to serious.

Common Side Effects

  • Diarrhea
  • Nausea
  • Headache
  • Pain at the application site
  • Cold-like symptoms (e.g., cough, runny nose, nasal congestion, sore throat)
  • Trouble sleeping

Serious or Rare Side Effects

  • Application site urticaria
  • Severe allergic reactions, such as rash, itching, swelling, severe dizziness, or trouble breathing.

Precautions & Warnings

Zoryve 0.15% should be used with caution and under medical supervision.

  • Allergy: Do not use if allergic to roflumilast or any of its ingredients.
  • Liver impairment: Use with caution in patients with moderate to severe liver impairment.
  • Pregnancy: Consult a doctor before use during pregnancy.
  • Children: Not established for use in children under 6 years of age.
  • Application: Avoid contact with eyes, mouth, or vagina; rinse immediately if contact occurs.
  • Storage: Store at room temperature, protect from light and moisture, and keep out of reach of children.

Avoid Interactions

Zoryve 0.15% may interact with other medications, requiring careful monitoring.

Major Interactions (Avoid)

  • None identified.

Moderate Interactions (Monitor Closely)

  • Other PDE4 inhibitors: May increase the risk of side effects.
  • Liver enzymes: May affect the metabolism of roflumilast, requiring dose adjustments.
  • Immunosuppressants: May enhance the immunosuppressive effects.

Frequently Asked Questions

Zoryve 0.15% is a topical cream containing roflumilast, a phosphodiesterase-4 (PDE4) inhibitor. It is primarily used to treat mild to moderate atopic dermatitis, also known as eczema, in patients aged 6 years and older. The cream helps reduce inflammation, redness, and itching associated with this chronic skin condition.

Roflumilast works by inhibiting the enzyme phosphodiesterase-4 (PDE4), which is responsible for breaking down cyclic AMP in cells. By inhibiting PDE4, roflumilast increases the levels of cyclic AMP, leading to a reduction in the production of inflammatory cytokines. This anti-inflammatory effect helps alleviate symptoms of skin conditions like atopic dermatitis.

The usual dose of Zoryve 0.15% is applied to the affected areas of the skin once daily. The cream should be rubbed in completely. The prescriber will determine the appropriate duration of treatment based on the patient's condition and response to the medication.

The safety of Zoryve 0.15% during pregnancy or breastfeeding has not been established. It is important to consult with a healthcare provider before using this medication if you are pregnant, planning to become pregnant, or breastfeeding. The potential benefits and risks should be carefully considered.

To order Zoryve 0.15% from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will then provide pricing, availability, shipping details, and the necessary import paperwork.

Zoryve 0.15% is a topical PDE4 inhibitor specifically designed to reduce inflammation in the skin. Compared to other treatments like topical corticosteroids, Zoryve 0.15% offers a non-steroidal option that can be used for longer periods without the risk of skin thinning. However, the choice of treatment depends on individual patient needs and should be discussed with a healthcare provider.

Zoryve 0.15% should be stored at room temperature, protected from light and moisture. Keep the cream out of reach of children. Avoid freezing the medication. Always follow the storage instructions provided on the packaging or by your healthcare provider to ensure the medication remains effective.

Zoryve 0.15% is applied topically to the affected areas of the skin once daily. The cream should be gently rubbed in until it is completely absorbed. Wash your hands after applying the cream, unless you are treating your hands. Avoid getting the cream in your eyes, mouth, or vagina, and rinse immediately with plenty of water if contact occurs.

The most serious risks associated with Zoryve 0.15% include severe allergic reactions, such as rash, itching, swelling, severe dizziness, or trouble breathing. Application site urticaria (hives) has also been reported. If you experience any of these symptoms, seek medical attention immediately.

Zoryve 0.15% should not be used by individuals who are allergic to roflumilast or any of its ingredients. It is also not recommended for use in children under 6 years of age, as its safety and effectiveness in this age group have not been established. Patients with moderate to severe liver impairment should use this medication with caution.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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