Product image of Zoryve 0.3 % (Roflumilast) 0.3 % FOAM supplied by GNH India

Zoryve 0.3 %

Active Ingredient:
Roflumilast
Form:
FOAM
Brand:
ZORYVE
Origin:
CANADA

Zoryve 0.3 % (Roflumilast FOAM) 0.3 %

Roflumilast, the active ingredient in ZORYVE 0.3% Foam, is a phosphodiesterase-4 (PDE4) inhibitor presented as a 0.3% foam for topical use. It is used to treat seborrheic dermatitis and plaque psoriasis in adults and children aged 9 years and older. GNH India supplies ZORYVE 0.3% Foam as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

ZORYVE 0.3% Foam is a prescription medication designed to address specific skin conditions. It is applied once daily to the affected areas and is known for its steroid-free formulation, making it a suitable option for long-term use.

Strength

0.3 %

Manufacturer / TM Owner

ARCUTIS CANADA, INC.

1
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Indications & Clinical Uses

ZORYVE 0.3% Foam is a topical medication used to manage skin conditions by reducing inflammation and other symptoms.

  • Seborrheic Dermatitis: Reduces flaking, redness, and itching associated with this condition.
  • Plaque Psoriasis: Helps manage symptoms such as scaling and inflammation on the scalp and body.
  • Atopic Dermatitis: Used to treat mild to moderate eczema, reducing inflammation and discomfort.

How It Works

  • Roflumilast works by selectively inhibiting phosphodiesterase-4 (PDE4), an enzyme that degrades cyclic AMP (cAMP). By inhibiting PDE4, roflumilast increases intracellular cAMP levels, which leads to a reduction in the production of inflammatory cytokines. This mechanism helps to reduce inflammation and the symptoms associated with skin conditions like seborrheic dermatitis and psoriasis.

Side Effects

ZORYVE 0.3% Foam may cause various side effects, ranging from common to serious.

Common Side Effects

  • Headache: A frequent side effect that may occur during treatment.
  • Diarrhea: Some users may experience gastrointestinal discomfort.
  • Nausea: Mild to moderate nausea can occur.
  • Upper respiratory tract infections: Symptoms such as a runny nose or sore throat may be observed.
  • Application site pain: Discomfort or pain at the site where the foam is applied.
  • Insomnia: Difficulty sleeping may be experienced by some users.
  • Urinary tract infections: Some users may develop UTIs.

Serious or Rare Side Effects

  • Severe allergic reactions: Rare but possible, requiring immediate medical attention.
  • Liver function abnormalities: Monitoring liver function is advised, especially in patients with pre-existing liver conditions.

Precautions & Warnings

ZORYVE 0.3% Foam should be used with caution and under medical supervision.

  • Allergies: Do not use if allergic to roflumilast or any of the ingredients.
  • Liver problems: Use with caution in patients with liver impairment.
  • Pregnancy: Consult a healthcare provider before use during pregnancy.
  • Breastfeeding: Avoid applying to the nipple or areola to prevent contact with the baby.
  • Children: Not recommended for children under 9 years of age for seborrheic dermatitis.
  • Flammability: Avoid fire, flame, and smoking during and after application.
  • Store at room temperature: Protect from light and moisture, and keep out of reach of children.

Avoid Interactions

ZORYVE 0.3% Foam may interact with other medications, potentially affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors: Can increase the risk of side effects.
  • Strong CYP3A4 inducers: May reduce the effectiveness of roflumilast.

Moderate Interactions (Monitor Closely)

  • Other PDE4 inhibitors: May enhance the risk of side effects.
  • Medications affecting liver function: Requires monitoring of liver function tests.
  • Immunosuppressants: May increase the risk of infections.

Frequently Asked Questions

ZORYVE 0.3% Foam is used to treat seborrheic dermatitis and plaque psoriasis. It helps reduce symptoms such as flaking, redness, and itching associated with these skin conditions. The foam is applied once daily to the affected areas and is known for its steroid-free formulation, making it suitable for long-term use.

Roflumilast works by inhibiting phosphodiesterase-4 (PDE4), an enzyme that degrades cyclic AMP (cAMP). By inhibiting PDE4, roflumilast increases intracellular cAMP levels, which leads to a reduction in the production of inflammatory cytokines. This mechanism helps to reduce inflammation and the symptoms associated with skin conditions like seborrheic dermatitis and psoriasis.

The usual dose of ZORYVE 0.3% Foam is determined by a healthcare provider based on the patient's condition and response to treatment. It is typically applied once daily to the affected areas. The prescriber will set the appropriate dosage and duration of treatment.

The safety of ZORYVE 0.3% Foam during pregnancy has not been established. It should not be used during pregnancy unless the benefits outweigh the risks. For breastfeeding women, it is advised to use the foam on the smallest area of the skin and for the shortest time needed. Avoid applying it directly to the nipple or areola to prevent contact with the baby.

To order ZORYVE 0.3% Foam from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will then provide pricing, availability, shipping details, and the necessary import paperwork.

ZORYVE 0.3% Foam is a steroid-free treatment option for seborrheic dermatitis, making it suitable for long-term use. Unlike topical steroids, it does not carry the risk of skin thinning or other steroid-related side effects. It is particularly effective for reducing inflammation and symptoms such as flaking and itching.

ZORYVE 0.3% Foam should be stored at room temperature, protected from light and moisture. Keep it out of reach of children. The foam is flammable, so avoid fire, flame, and smoking during and after application. Always follow the storage instructions provided with the medication.

ZORYVE 0.3% Foam is applied topically once daily to the affected areas. The foam should be gently massaged into the skin. Wash your hands with soap and water after applying the foam, unless you are treating areas on your hands. Avoid contact with the eyes, mouth, and vagina.

The most serious risks associated with ZORYVE 0.3% Foam include severe allergic reactions and liver function abnormalities. Patients with pre-existing liver conditions should be monitored closely. If you experience symptoms such as rash, itching, swelling, severe diarrhea, or signs of liver problems, seek medical attention immediately.

ZORYVE 0.3% Foam should not be used by individuals who are allergic to roflumilast or any of the ingredients in the foam. It is also not recommended for children under 9 years of age for the treatment of seborrheic dermatitis. Patients with moderate to severe liver impairment should use it with caution and under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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