Estring Vaginal Ring-DE - Estradiol

Storage/Handling:

Store vials should be stored refrigerated at a room temperature. protected from sunlight.

Uses of Estring Vaginal Ring-DE - Estradiol:

Estring vaginal ring is used in the management of vaginal and urinary menopausal symptoms.

Product Introduction:

The Estring 2mg Vaginal Ring falls under the category of medications known as local estrogen replacement therapy. It is prescribed for addressing menopausal symptoms affecting the vagina and urinary tract, including sensations of vaginal dryness (with or without itching), painful intercourse, discomfort during urination, or an increased urge to urinate.

Estrogen, a female hormone produced by the ovaries, diminishes with the onset of menopause, leading to associated symptoms. The estradiol vaginal ring operates by delivering localized estrogen action. However, it doesn't supply sufficient estrogen to alleviate other menopausal symptoms like hot flashes.

When addressing solely the vaginal symptoms associated with menopause, it is recommended to prioritize the use of products applied directly within the vagina, such as this particular medication. Estrogens administered orally, absorbed through the skin, or injected may pose increased risks of side effects, attributed to higher levels of estrogen absorption in the body.

Administered over a 90-day period, the Estring 2mg vaginal ring consistently releases estrogen into the vaginal area. The complete therapeutic effects may take approximately 2 to 3 weeks to manifest. Should your symptoms persist beyond this period, it is advisable to seek guidance from your healthcare provider.

Side Effects of Estring Vaginal Ring-DE - Estradiol:

Medications may exhibit specific side effects during their use. The following outlines some of the potential side effects associated with Estring 2mg. Please promptly notify your doctor if you encounter any of these symptoms.

• Nausea/vomiting

• Bloating

• increased vaginal discharge

• breast tenderness or pain

• Headache or weight

• Vaginal irritation at application site

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Tell your doctor right away if you have any serious side effects, including:

• nausea/vomiting that doesn't stop

• mental/mood changes (such as depression, memory loss)

• breast lumps

• unusual vaginal bleeding (such as spotting, breakthrough bleeding, prolonged/recurrent bleeding)

• unusual vaginal irritation/itching/odor/discharge

• severe stomach/abdominal pain

• yellowing eyes/skin

• dark urine

• swelling hands/ankles/feet

• increased thirst/urination

This medication may rarely cause serious problems from blood clots (such as heart attacks, strokes, deep vein thrombosis, pulmonary embolism).

Contact medical help right away if you experience more such serious symptoms such as:

• chest/jaw/left arm pain

• unusual sweating

• sudden/severe headache

• weakness on one side of the body

• confusion

• trouble speaking

• sudden vision changes (such as partial/complete blindness)

• pain/redness/swelling of legs

• tingling/weakness/numbness in the arms/legs

• trouble breathing

• coughing up blood

• sudden dizziness/fainting.

Drug Interactions:

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include:

• aromatase inhibitors (such as anastrozole, exemestane, letrozole)

• Fezolinetant

• Fulvestrant

• Ospemifene

• Raloxifene

• Tamoxifen

• toremifene

• tranexamic acid.

This medication may interfere with certain lab tests, possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

How Estring Vaginal Ring-DE - Estradiol Works:

In females, the body experiences a reduction in estrogen production following menopause. Estring (estradiol) is a pliable and soft ring employed post-menopause to deliver a consistent release of estrogen over a period of three months. Its purpose is to address menopausal alterations occurring in and around the vaginal area.

Safety Instructions For Estring Vaginal Ring-DE - Estradiol:

ALCOHOL Exercise caution Exercise caution when consuming alcohol while using Estring 2mg Vaginal Ring. Alcohol may interact with the medication, potentially leading to adverse effects or diminishing its efficacy. It is advisable to consult with a healthcare professional regarding the specific considerations related to alcohol consumption during the use of Estring.. PREGNANCY consult your doctor If you are pregnant or planning to become pregnant, discuss the use of Estring with your healthcare doctor. They can provide guidance on the potential risks and benefits, helping you make an informed decision about its use during pregnancy. BREAST FEEDING consult your doctor Consult your healthcare professional before using Estring 2mg if you are breastfeeding. They can offer advice on the safety of the medication during lactation and provide alternatives if necessary.. Driving exercise caution Be mindful of your ability to drive while using an Estring 2mg Vaginal Ring. Some individuals may experience side effects that could impair their cognitive or motor skills. If you notice any adverse effects that may affect your ability to drive safely, refrain from operating vehicles and seek guidance from your healthcare provider. LIVER Inform your doctor Inform your healthcare provider about any existing liver conditions before using Estring. They can assess the potential impact of the medication on liver function and recommend appropriate monitoring or adjustments to ensure your safety. KIDNEY inform your doctor If you have kidney issues or are undergoing kidney-related treatment, inform your healthcare provider. They can evaluate the suitability of Estring for your condition and make necessary adjustments to ensure its safe use. CHILDREN not recommended Estring 2mg Vaginal Ring is not intended for use in children.

Habit Forming

No

Remember:

1. The use of this medication may lead to the development of discolored patches or dark areas on your face and skin, a condition known as melasma. Exposure to sunlight can exacerbate this effect, so it's advisable to minimize sun exposure.
2. This product might contain inactive ingredients that could trigger allergic reactions or other adverse effects. It's important to be aware of the ingredients and discuss any concerns with your healthcare provider.
3. Refrain from smoking or using tobacco while using this medication. Combining estrogens with smoking heightens the risk of stroke, blood clots, high blood pressure, and heart attack, particularly in women over the age of 35.
4. The estradiol vaginal ring releases estrogen directly into the vagina, minimizing the likelihood of drug interactions compared to estrogen medications taken orally.
5. Research suggests an elevated risk of heart disease and stroke in postmenopausal women using estrogen, either alone or in combination with progestin.
6. In the event that the vaginal ring becomes dislodged from the vagina, rinse it with lukewarm water and reinsert it. If the ring frequently falls out, contact your doctor for further guidance and assistance.

FAQs:

1. What is Estring and how does it work?

Estring is a vaginal ring that contains estrogen. It is used to treat symptoms of menopause, such as vaginal dryness and irritation. The ring continuously releases a low dose of estrogen locally in the vaginal area, helping to relieve these symptoms.

2. How is Estring inserted?

Estring is a soft, flexible ring that is inserted into the vagina by the patient. It is typically inserted by folding it and pushing it into the vaginal canal as far as it will comfortably go. The ring remains in place for a period of three months, after which it is removed and replaced with a new ring.

3. Can Estring be used by women with certain medical conditions?

Estring may not be suitable for women with a history of certain medical conditions, such as breast cancer, uterine cancer, or liver disease. It is important to discuss your medical history with your

4. Can Estring be used during sexual intercourse?

Estring is designed to remain in place during normal daily activities, including sexual intercourse. However, if you or your partner experience discomfort during intercourse while using Estring, it is advisable to remove the ring temporarily and reinsert it afterwards.