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Benztropine Mesylate (Benztropine Mesylate)

Trade Name : Benztropine Mesylate

West-Ward Pharmaceuticals Corp

INJECTION

Strength 1 mg/mL

BENZTROPINE MESYLATE Anticholinergic [EPC],Antihistamine [EPC],Cholinergic Antagonists [MoA],Histamine Receptor Antagonists [MoA]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Benztropine Mesylate (Benztropine Mesylate) which is also known as Benztropine Mesylate and Manufactured by West-Ward Pharmaceuticals Corp. It is available in strength of 1 mg/mL per ml. Read more

Benztropine Mesylate (Benztropine Mesylate) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • Rxu00a0Only
  • Benztropineu00a0Mesylate, USP is a synthetic compound containing structural features found in atropine and diphenhydramine.
  • It is designated chemically as 8-azabicyclo[3.2.1] octane, 3-(diphenylmethoxy)-, endo, methanesulfonate. Its empirical formula is CHNOu2022CHOS, and its structural formula is:
  • Benztropine mesylate is a crystalline white powder, very soluble in water, and has a molecular weight of 403.54.
  • Benztropine Mesylate Injection, USP is supplied as a sterile injection for intravenous and intramuscular use.
  • Each milliliter of the injection contains: Benztropine Mesylate, USP:u00a0 .............................................................................................1 mg Sodium Chloride, USP:u00a0 .....................................................................................................9 mgWater for Injection q.s:u00a0 ......................................................................................................1 mL
  • Benztropine mesylate possesses both anticholinergic and antihistaminic effects, although only the former have been established as therapeutically significant in the management of parkinsonism.
  • In the isolated guinea pig ileum, the anticholinergic activity of this drug is about equal to that of atropine; however, when administered orally to unanesthetized cats, it is only about half as active as atropine.
  • In laboratory animals, its antihistaminic activity and duration of action approach those of pyrilamine maleate.
  • For use as an adjunct in the therapy of all forms of parkinsonism (see ).
  • Useful also in the control of extrapyramidal disorders (except tardive dyskinesia u2014 see ) due to neuroleptic drugs (e.g., phenothiazines).
  • Hypersensitivity to any component of benztropine mesylate.
  • Because of its atropine-like side effects, this drug is contraindicated in pediatric patients under three years of age, and should be used with caution in older pediatric patients.
  • Safe use in pregnancy has not been established.
  • Benztropine mesylate may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle.
  • When benztropine mesylate is given concomitantly with phenothiazines, haloperidol, or other drugs with anticholinergic or antidopaminergic activity, patients should be advised to report gastrointestinal complaints, fever or heat intolerance promptly. Paralytic ileus, hyperthermia and heat stroke, all of which have sometimes been fatal, have occurred in patients taking anticholinergic-type antiparkinsonism drugs, including benztropine mesylate, in combination with phenothiazines and/or tricyclic antidepressants.
  • Since benztropine mesylate contains structural features of atropine, it may produce anhidrosis. For this reason, it should be administered with caution during hot weather, especially when given concomitantly with other atropine-like drugs to the chronically ill, the alcoholic, those who have central nervous system disease, and those who do manual labor in a hot environment. Anhidrosis may occur more readily when some disturbance of sweating already exists. If there is evidence of anhidrosis, the possibility of hyperthermia should be considered. Dosage should be decreased at the discretion of the physician so that the ability to maintain body heat equilibrium by perspiration is not impaired. Severe anhidrosis and fatal hyperthermia have occurred.
  • No data
  • The adverse reactions below, most of which are anticholinergic in nature, have been reported and within each category are listed in order of decreasing severity.
  • No data
  • Since there is no significant difference in onset of effect after intravenous or intramuscular injection, usually there is no need to use the intravenous route. The drug is quickly effective after either route, with improvement sometimes noticeable a few minutes after injection. In emergency situations, when the condition of the patient is alarming, 1 to 2 mL of the injection normally will provide quick relief. If the parkinsonian effect begins to return, the dose can be repeated.
  • Because of cumulative action, therapy should be initiated with a low dose which is increased gradually at five or six-day intervals to the smallest amount necessary for optimal relief. Increases should be made in increments of 0.5 mg, to a maximum of 6 mg, or until optimal results are obtained without excessive adverse reactions.
  • Benztropine Mesylate Injection, USP, 1 mg per mL, is a clear, colorless solution and is supplied as follows:
  • NDC 0143-9729-05 in boxes of 5 x 2 mL ampules.
  • Storage Conditions:
  • Manufactured by:
  • Distributed by:
  • Revised: 03/2014PIN219-WES/2
  • NDC 0143-9729-05BENZTROPINE MESYLATE INJECTION, USP2 mg/2 mL(1 mg/mL)FOR IV OR IM USERx ONLY
  • No data

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