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Estradiol Cypionate (Depo-Estradiol)

Trade Name : Depo-Estradiol

Pharmacia and Upjohn Company LLC

INJECTION

Strength 5 mg/mL

ESTRADIOL CYPIONATE Estradiol Congeners [CS],Estrogen [EPC],Estrogen Receptor Agonists [MoA]

Delivery Process

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Estradiol Cypionate (Depo-Estradiol) which is also known as Depo-Estradiol and Manufactured by Pharmacia and Upjohn Company LLC. It is available in strength of 5 mg/mL per ml. Read more

Estradiol Cypionate (Depo-Estradiol) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • No data
  • DEPO-Estradiol Injection contains estradiol cypionate for intramuscular use. Each mL contains:
  • 5 mg/mLu20145 mg estradiol cypionate, 5.4 mg chlorobutanol anhydrous (chloral derivative) added as preservative; in 913 mg cottonseed oil.
  • Warning:
  • DEPO-Estradiol contains an oil soluble ester of estradiol 17u03b2. The chemical name for estradiol cypionate is estradiol 17-cyclopentanepropionate.
  • Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol, at the receptor level.
  • The primary source of estrogen in normally cycling adult women is the ovarian follicle, which secretes 70 to 500 mcg of estradiol daily, depending on the phase of the menstrual cycle. After menopause, most endogenous estrogen is produced by conversion of androstenedione, secreted by the adrenal cortex, to estrone by peripheral tissues. Thus, estrone and the sulfate conjugated form, estrone sulfate, are the most abundant circulating estrogens in postmenopausal women.
  • Estrogens act through binding to nuclear receptors in estrogen-responsive tissues. To date, two estrogen receptors have been identified. These vary in proportion from tissue to tissue.
  • Circulating estrogens modulate the pituitary secretion of the gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), through a negative feedback mechanism. Estrogens act to reduce the elevated levels of these hormones seen in postmenopausal women.
  • DEPO-Estradiol Injection is indicated in the treatment of:
  • Estrogens should not be used in individuals with any of the following conditions:
  • There appears to be little or no increased risk of birth defects in children born to women who have used estrogens and progestins from oral contraceptives inadvertently during early pregnancy. (See .)
  • See n
  • No data
  • See and n
  • The following additional adverse reactions have been reported with estrogens and/or progestin therapy.
  • Chlorobutanol anhydrous (chloral derivative) added as a preservative may be habit forming.
  • Serious ill effects have not been reported following acute ingestion of large doses of estrogen-containing oral contraceptives by young children. Overdosage of estrogen may cause nausea and vomiting, and withdrawal bleeding may occur in females.
  • Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.
  • Warming and shaking the vial should redissolve any crystals that may have formed during storage at temperatures lower than recommended.
  • DEPO-Estradiol INJECTION IS FOR INTRAMUSCULAR USE ONLY.
  • When estrogen is prescribed for a woman with a uterus, progestin should also be initiated to reduce the risk of endometrial cancer. A woman without a uterus does not need progestin. Use of estrogen, alone or in combination with a progestin, should be with the lowest effective dose and for the shortest duration consistent with treatment goals and risks for the individual woman. Patients should be reevaluated periodically as clinically appropriate (e.g., 3-month to 6-month intervals) to determine if treatment is still necessary. (See and .) For women who have a uterus, adequate diagnostic measures, such as endometrial sampling, when indicated, should be undertaken to rule out malignancy in cases of undiagnosed persistent or recurring abnormal vaginal bleeding.
  • DEPO-Estradiol Injection is available in the following concentration containing per mL:
  • 5 mg
  • WARNING:
  • Store at controlled room temperature 20u00b0 to 25u00b0 C (68u00b0 to 77u00b0 F) [see USP].
  • No data
  • LAB-0083-5.0 Revised June 2019
  • DEPO-Estradioln
  • Brand of estradiol cypionate injection, USP
  • Read this PATIENT INFORMATION before you start taking DEPO-Estradiol and read what you get each time you refill DEPO-Estradiol. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.
  • 5 mL Vial
  • Depo-Estradiol
  • 5 mg/mL
  • For intramuscular use onlyMADE IN USA(includes foreign content)
  • Rx only
  • NDC 0009-0271-01n n
  • 1u20135 mL Vial
  • Depo-Estradiol
  • 5 mg/mL
  • For intramuscular use only
  • Pfizer Injectables

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