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Fluocinonide (Fluocinonide)

Trade Name : Fluocinonide

Teva Pharmaceuticals USA, Inc.

CREAM

Strength 0.5 mg/g

FLUOCINONIDE Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Fluocinonide (Fluocinonide) which is also known as Fluocinonide and Manufactured by Teva Pharmaceuticals USA, Inc.. It is available in strength of 0.5 mg/g per ml. Read more

Fluocinonide (Fluocinonide) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. The topical corticosteroids are intended for topical administration. The active component is the corticosteroid fluocinonide, which is the 21-acetate ester of fluocinolone acetonide and has the chemical name pregna-1,4-diene-3,20-dione,21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene) bis(oxy)]-,(6u03b1, 11u03b2, 16u03b1)-. It has the following structural formula:
  • CHF0 M.W. 494.52
  • Each gram of Fluocinonide Cream USP, 0.05% (Emulsified Base) contains: 0.5 mg fluocinonide, USP in a water-washable aqueous emollient base of stearyl alcohol, cetyl alcohol, mineral oil, propylene glycol, sorbitan monostearate, polysorbate 60, citric acid monohydrate and purified water.
  • Each gram of Fluocinonide Cream USP, 0.05% contains: 0.5 mg fluocinonide, USP in a specially formulated cream base consisting of stearyl alcohol, polyethylene glycol 8000, propylene glycol, 1,2,6-hexanetriol and citric acid monohydrate. This white cream vehicle is greaseless, non-staining, anhydrous and completely water miscible. The base provides emollient and hydrophilic properties.
  • In this formulation, the active ingredient is totally in solution.
  • Each gram of Fluocinonide Ointment USP, 0.05% contains: 0.5 mg fluocinonide, USP in an ointment base consisting of white petrolatum, castor oil, and sorbitan sesquioleate. It provides the occlusive and emollient effects desirable in an ointment.
  • In this formulation, the active ingredient is totally in solution.
  • Topical corticosteroids share anti-inflammatory, antipruritic and vasoconstrictive actions.
  • The mechanism of anti-inflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.
  • The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings.
  • Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses. (See ).
  • Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.
  • The topical corticosteriods are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
  • The topical corticosteriods are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.
  • No data
  • The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence:
  • Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects. (See ).
  • The topical corticosteroids are generally applied to the affected area as a thin film from two to four times daily depending on the severity of the condition.
  • Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions.
  • If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted.
  • Fluocinonide Cream USP, 0.05% (Emulsified Base) is supplied in 15 gram (NDC 0093-0263-15), 30 gram (NDC 0093-0263-30), and 60 gram (NDC 0093-0263-92) tubes.
  • Fluocinonide Cream USP, 0.05% is supplied in 15 gram (NDC 0093-0262-15), 30 gram (NDC 0093-0262-30), and 60 gram (NDC 0093-0262-92) tubes.
  • Fluocinonide Ointment USP, 0.05% is supplied in 15 gram (NDC 0093-0264-15), 30 gram (NDC 0093-0264-30), and 60 gram (NDC 0093-0264-92) tubes.
  • Store at 20u00b0 to 25u00b0C (68u00b0 to 77u00b0F) [See USP Controlled Room Temperature].
  • Avoid excessive heat, above 40u00b0C (104u00b0F).
  • Manufactured In Croatia By:
  • PLIVA HRVATSKA d.o.o.
  • Zagreb, Croatia
  • Manufactured For:
  • TEVA PHARMACEUTICALS USA, INC.
  • North Wales, PA 19454
  • Rev. P 2/2016
  • No data
  • No data
  • No data

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Comparator Sourcing for Clinical Trials

Comparator Sourcing for Clinical Trials

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Validated Cold Chain Shipment

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