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Methsuximide (Celontin)

Trade Name : Celontin

Parke-Davis Div of Pfizer Inc

CAPSULE

Strength 300 mg/1

METHSUXIMIDE Anti-epileptic Agent [EPC],Decreased Central Nervous System Disorganized Electrical Activity [PE]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Methsuximide (Celontin) which is also known as Celontin and Manufactured by Parke-Davis Div of Pfizer Inc. It is available in strength of 300 mg/1 per ml. Read more

Methsuximide (Celontin) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • Celontin (methsuximide) is an anticonvulsant succinimide, chemically designated as N,2-Dimethyl-2-phenylsuccinimide, with the following structural formula:
  • Each Celontin capsule contains 300 mg methsuximide, USP. Also contains starch, NF. The capsule contains colloidal silicon dioxide, NF; D&C yellow No. 10; FD&C yellow No. 6; gelatin, NF; and sodium lauryl sulfate, NF.
  • Methsuximide suppresses the paroxysmal three cycle per second spike and wave activity associated with lapses of consciousness which is common in absence (petit mal) seizures. The frequency of epileptiform attacks is reduced, apparently by depression of the motor cortex and elevation of the threshold of the central nervous system to convulsive stimuli.
  • Celontin is indicated for the control of absence (petit mal) seizures that are refractory to other drugs.
  • Methsuximide should not be used in patients with a history of hypersensitivity to succinimides.
  • No data
  • No data
  • Gastrointestinal System:
  • Hemopoietic System:
  • Nervous System
  • Integumentary System
  • Cardiovascular
  • Genitourinary System
  • Body as a Whole
  • Acute overdoses may produce nausea, vomiting, and CNS depression including coma with respiratory depression. Methsuximide poisoning may follow a biphasic course. Following an initial comatose state, patients have awakened and then relapsed into a coma within 24 hours. It is believed that an active metabolite of methsuximide, N-desmethylmethsuximide, is responsible for this biphasic profile. It is important to follow plasma levels of N-desmethylmethsuximide in methsuximide poisonings. Levels greater than 40 u00b5g/mL have caused toxicity, and coma has been seen at levels of 150 u00b5g/mL.
  • Treatment should include emesis (unless the patient is or could rapidly become obtunded, comatose, or convulsing) or gastric lavage, activated charcoal, cathartics, and general supportive measures. Charcoal hemoperfusion may be useful in removing the N-desmethyl metabolite of methsuximide. Forced diuresis and exchange transfusions are ineffective.
  • Optimum dosage of Celontin must be determined by trial. A suggested dosage schedule is 300 mg per day for the first week. If required, dosage may be increased thereafter at weekly intervals by 300 mg per day for the three weeks following to a daily dosage of 1.2 g. Because therapeutic effect and tolerance vary among patients, therapy with Celontin must be individualized according to the response of each patient. Optimal dosage is that amount of Celontin which is barely sufficient to control seizures so that side effects may be kept to a minimum.
  • Celontin may be administered in combination with other anticonvulsants when other forms of epilepsy coexist with absence (petit mal).
  • N 0071-0525-24 (P-D 525)u2013Celontin Capsules, #1 capsule each containing 300 mg methsuximide; bottles of 100.
  • Store at 25u00b0C (77u00b0F); excursions permitted to 15u201330u00b0C (59u201386u00b0F) [see USP Controlled Room Temperature].
  • Protect from light and moisture. Protect from excessive heat 40u00b0C (104u00b0F).
  • LAB-0156-6.0November 2013
  • CELONTIN (Suh lu014fn' tu012dn)(methsuximide)
  • Capsules
  • Read this Medication Guide before you start taking CELONTIN and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or treatment. If you have any questions about CELONTIN, ask your healthcare provider or pharmacist.
  • What is the most important information I should know about CELONTIN?
  • Do not stop taking CELONTIN without first talking to your healthcare provider.
  • CELONTIN can cause serious side effects, including:
  • What is CELONTIN?
  • CELONTIN is a prescription medicine used to treat absence (petit mal) seizures that have not gotten better with other seizure medicines.
  • Who should not take CELONTIN?
  • Do not take CELONTIN if you are allergic to succinimides (methsuximide or ethosuximide) or any of the ingredients in CELONTIN. See the end of this Medication Guide for a complete list of ingredients in CELONTIN.
  • What should I tell my healthcare provider before taking CELONTIN?
  • Before you take CELONTIN, tell your healthcare provider if you:
  • Tell your healthcare provider about all the medicines you take
  • Know the medicines you take. Keep a list of them with you to show your healthcare provider and pharmacist each time you get a new medicine.
  • How should I take CELONTIN?
  • What should I avoid while taking CELONTIN?
  • What are the possible side effects of CELONTIN?
  • CELONTIN may cause other serious side effects, including:
  • The most common side effects of CELONTIN include:
  • Tell your healthcare provider about any side effect that bothers you or that does not go away.
  • These are not all the possible side effects with CELONTIN. For more information, ask your healthcare provider or pharmacist.
  • Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088n
  • How should I store CELONTIN?
  • Keep CELONTIN and all medicines out of the reach of children
  • General information about CELONTIN
  • Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use CELONTIN for a condition for which it was not prescribed. Do not give CELONTIN to other people, even if they have the same condition. It may harm them.
  • This Medication Guide summarizes the most important information about CELONTIN. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about CELONTIN that is written for healthcare professionals.
  • For more information, go to www.pfizer.com or call 1-800-438-1985.
  • What are the ingredients in CELONTIN?
  • Active ingredient:
  • Inactive ingredients:
  • This Medication Guide has been approved by the U.S. Food and Drug Administration.
  • LAB-0404-2.0August 2013
  • Pfizer
  • ALWAYS DISPENSE WITH MEDICATION GUIDENDC 0071-0525-24
  • Celontinn (Methsuximide Capsules, USP)
  • 300 mg
  • 100 Capsules

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