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Naloxone Hydrochloride (Narcan)

Trade Name : Narcan

Adapt Pharma Inc

SPRAY

Strength 4 mg/.1mL

NALOXONE HYDROCHLORIDE Opioid Antagonist [EPC],Opioid Antagonists [MoA]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Naloxone Hydrochloride (Narcan) which is also known as Narcan and Manufactured by Adapt Pharma Inc. It is available in strength of 4 mg/.1mL per ml. Read more

Naloxone Hydrochloride (Narcan) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • NARCAN Nasal Spray is indicated for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression.
  • NARCAN Nasal Spray is intended for immediate administration as emergency therapy in settings where opioids may be present.
  • NARCAN Nasal Spray is not a substitute for emergency medical care.
  • Limitations of Use:
  • Restrict prescription of NARCAN Nasal Spray 2 mg to opioid-dependent patients expected to be at risk for severe opioid withdrawal in situations where there is a low risk for accidental or intentional opioid exposure by household contacts.
  • NARCAN Nasal Spray is an opioid antagonist indicated for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression. ()
  • NARCAN Nasal Spray is intended for immediate administration as emergency therapy in settings where opioids may be present. ()
  • NARCAN Nasal Spray is not a substitute for emergency medical care. ()
  • No data
  • NARCAN Nasal Spray is supplied as a single-dose intranasal spray containing 2 mg or 4 mg of naloxone hydrochloride in 0.1 mL.
  • Nasal spray: 2 mg and 4 mg of naloxone hydrochloride in 0.1 mL. ()
  • NARCAN Nasal Spray is contraindicated in patients known to be hypersensitive to naloxone hydrochloride or to any of the other ingredients.
  • Hypersensitivity to naloxone hydrochloride. ()
  • No data
  • Risk of Recurrent Respiratory and CNS Depression
  • Risk of Limited Efficacy with Partial Agonists or Mixed Agonists/Antagonists
  • Precipitation of Severe Opioid Withdrawal
  • Risk of Cardiovascular (CV) Effects:
  • The following serious adverse reactions are discussed elsewhere in the labeling:
  • Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to the rates in the clinical studies of another drug and may not reflect the rates observed in practice.
  • The following adverse reactions were observed in a NARCAN Nasal Spray clinical study.
  • In a pharmacokinetic study of 30 healthy adult volunteers exposed to one spray of NARCAN Nasal Spray in one nostril or two sprays of NARCAN Nasal Spray, one in each nostril, the most common adverse reactions were: increased blood pressure, constipation, toothache, muscle spasms, musculoskeletal pain, headache, nasal dryness, nasal edema, nasal congestion, nasal inflammation, rhinalgia, and xeroderma.
  • The following adverse reactions have been identified primarily during post-approval use of naloxone hydrochloride in the post-operative setting. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure: Hypotension, hypertension, ventricular tachycardia and fibrillation, dyspnea, pulmonary edema, and cardiac arrest. Death, coma, and encephalopathy have been reported as sequelae of these events. Excessive doses of naloxone hydrochloride in post-operative patients have resulted in significant reversal of analgesia, and have caused agitation.
  • Abrupt reversal of opioid effects in persons who were physically dependent on opioids has precipitated an acute withdrawal syndrome. Signs and symptoms have included: body aches, fever, sweating, runny nose, sneezing, piloerection, yawning, weakness, shivering or trembling, nervousness, restlessness or irritability, diarrhea, nausea or vomiting, abdominal cramps, increased blood pressure, tachycardia. In some patients, there may be aggressive behavior upon abrupt reversal of an opioid overdose. In the neonate, opioid withdrawal signs and symptoms also included convulsions, excessive crying, and hyperactive reflexes.
  • The following adverse reactions were observed in a NARCAN Nasal Spray clinical study: increased blood pressure, constipation, toothache, muscle spasms, musculoskeletal pain, headache, nasal dryness, nasal edema, nasal congestion, nasal inflammation, rhinalgia, and xeroderma. ()
  • To report SUSPECTED ADVERSE REACTIONS, contact Adapt Pharma, Inc. at 1-844-4NARCAN (1-844-462-7226) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
  • No data
  • NARCAN (naloxone hydrochloride) Nasal Spray is a pre-filled, single dose intranasal spray. Chemically, naloxone hydrochloride is the hydrochloride salt of 17-Allyl-4,5u03b1-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride with the following structure:
  • Naloxone hydrochloride, an opioid antagonist, occurs as a white to slightly off-white powder, and is soluble in water, in dilute acids, and in strong alkali; slightly soluble in alcohol; practically insoluble in ether and in chloroform.
  • Each NARCAN Nasal Spray contains a 2 mg or 4 mg single dose of naloxone hydrochloride (equivalent to 1.8 mg or 3.6 mg of naloxone) in a 0.1 mL (100 microliter) aqueous solution.
  • Inactive ingredients include benzalkonium chloride (preservative), disodium ethylenediaminetetraacetate (stabilizer), sodium chloride, hydrochloric acid to adjust pH, and purified water. The pH range is 3.5 to 5.5.
  • No data
  • No data
  • No data
  • Advise the patient and family members or caregivers to read the FDA-approved patient labeling ( and ).
  • NARCAN is a registered trademark licensed by Adapt Pharma Operations Limited.
  • Distributed by Adapt Pharma, Inc., Plymouth Meeting, PA 19462 USA
  • A1135
  • No data
  • You and your family members or caregivers should read the Instructions for Use that comes with NARCAN Nasal Spray before using it. Talk to your healthcare provider if you and your family members or caregivers have any questions about the use of NARCAN Nasal Spray.
  • Use NARCAN Nasal Spray for known or suspected opioid overdose in adults and children.
  • Important: For use in the nose only.
  • How to use NARCAN Nasal Spray:
  • What to do after NARCAN Nasal Spray has been used:
  • How should I store NARCAN Nasal Spray?
  • Keep NARCAN Nasal Spray and all medicines out of the reach of children.
  • This Instructions for Use has been approved by the U.S. Food and Drug Administration.
  • Distributed by Adapt Pharma, Inc. Plymouth Meeting, PA 19462 USA.
  • For more information, go to www.narcannasalspray.com or call 1-844-4NARCAN (1-844-462-7226).
  • Issued: 08/2020
  • A1135
  • NDC 69547-212-040.1 mL intranasal spray per unitFor use in the nose onlyRx Only
  • NARCAN(naloxone HCl)NASAL SPRAY 2 mg
  • Use NARCAN Nasal Spray for known or suspected opioid overdose in adults and children.
  • Important: For use in the nose only.
  • Do not remove or test the NARCAN Nasal Spray until ready to use.
  • This box contains four (4) 2-mg doses of naloxone HCl in 0.1 mL of nasal spray.
  • Four Pack
  • CHECK PRODUCT EXPIRATION DATE BEFORE USE.
  • NDC 69547-353-020.1 mL intranasal spray per unitFor use in the nose onlyRx Only
  • NARCAN(naloxone HCl)NASAL SPRAY 4 mg
  • Use NARCAN Nasal Spray for known or suspectedopioid overdose in adults and children.
  • Important: For use in the nose only.
  • Do not remove or test the NARCAN Nasal Sprayuntil ready to use
  • This box contains two (2) 4-mg doses of naloxoneHCl nasal spray
  • Two Pack
  • CHECK PRODUCT EXPIRATION DATE BEFORE USE.
  • OPEN HERE FOR QUICK START GUIDEOpioid Overdose Response Instructions

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