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Phenoxybenzamine Hydrochloride (Phenoxybenzamine Hydrochloride)

Trade Name : Phenoxybenzamine Hydrochloride

West-Ward Pharmaceuticals Corp.

CAPSULE

Strength 10 mg/1

PHENOXYBENZAMINE HYDROCHLORIDE Adrenergic alpha-Antagonists [MoA],alpha-Adrenergic Blocker [EPC]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Phenoxybenzamine Hydrochloride (Phenoxybenzamine Hydrochloride) which is also known as Phenoxybenzamine Hydrochloride and Manufactured by West-Ward Pharmaceuticals Corp.. It is available in strength of 10 mg/1 per ml. Read more

Phenoxybenzamine Hydrochloride (Phenoxybenzamine Hydrochloride) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • Rx only
  • Each Phenoxybenzamine Hydrochloride Capsule USP contains 10 mg of phenoxybenzamine hydrochloride USP. Inactive ingredients consist of anhydrous lactose, black monogramming ink, colloidal silicon dioxide and sodium lauryl sulfate. The black monogramming ink contains ammonium hydroxide, iron oxide black, isopropyl alcohol, N-butyl alcohol, propylene glycol, and shellac. The capsule shells also contain FD&C Red No. 40, gelatin, purified water and titanium dioxide.
  • Phenoxybenzamine is -(2-Chloroethyl)--(1-methyl-2-phenoxyethyl)benzylamine hydrochloride:
  • Phenoxybenzamine hydrochloride is a white to almost white, crystalline powder with a molecular weight of 340.3, which melts between 136u00b0 and 141u00b0C. It is soluble in alcohol and chloroform; insoluble in ether and water.
  • Phenoxybenzamine hydrochloride is a long-acting, adrenergic, -receptor blocking agent, which can produce and maintain u201cchemical sympathectomyu201d by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system.
  • Twenty to 30 percent of orally administered phenoxybenzamine appears to be absorbed in the active form.n
  • The half-life of orally administered phenoxybenzamine hydrochloride is not known; however, the half-life of intravenously administered drug is approximately 24 hours. Demonstrable effects with intravenous administration persist for at least 3 to 4 days, and the effects of daily administration are cumulative for nearly a week.n
  • Phenoxybenzamine hydrochloride capsules are indicated in the treatment of pheochromocytoma, to control episodes of hypertension and sweating. If tachycardia is excessive, it may be necessary to use a -blocking agent concomitantly.
  • Conditions where a fall in blood pressure may be undesirable; hypersensitivity to the drug or any of its components.
  • Phenoxybenzamine-induced -adrenergic blockade leaves -adrenergic receptors unopposed. Compounds that stimulate both types of receptors may, therefore, produce an exaggerated hypotensive response and tachycardia.
  • No data
  • The following adverse reactions have been observed, but there are insufficient data to support an estimate of their frequency.
  • Autonomic Nervous System*: Postural hypotension, tachycardia, inhibition of ejaculation, nasal congestion, miosis.
  • *These so-called u201cside effectsu201d are actually evidence of adrenergic blockade and vary according to the degree of blockade.
  • Miscellaneous: Gastrointestinal irritation, drowsiness, fatigue.
  • SYMPTOMS - These are largely the result of blocking of the sympathetic nervous system and of the circulating epinephrine. They may include postural hypotension, resulting in dizziness or fainting; tachycardia, particularly postural; vomiting; lethargy; shock.
  • When symptoms and signs of overdosage exist, discontinue the drug. Treatment of circulatory failure, if present, is a prime consideration. In cases of mild overdosage, recumbent position with legs elevated usually restores cerebral circulation. In the more severe cases, the usual measures to combat shock should be instituted. Usual pressor agents are effective. Epinephrine is contraindicated because it stimulates both - and - receptors; since receptors are blocked, the net effect of epinephrine administration is vasodilation and a further drop in blood pressure (epinephrine reversal).
  • The patient may have to be kept flat for 24 hours or more in the case of overdose, as the effect of the drug is prolonged. Leg bandages and an abdominal binder may shorten the period of disability.
  • I.V. Infusion of levarterenol bitartrate** may be used to combat severe hypotensive reactions, because it stimulates - receptors primarily. Although phenoxybenzamine hydrochloride is an -adrenergic blocking agent, a sufficient dose of levarterenol bitartrate will overcome this effect.
  • The oral LD for phenoxybenzamine hydrochloride is approximately 2000 mg/kg in rats and approximately 500 mg/kg in guinea pigs.
  • The dosage should be adjusted to fit the needs of each patient. Small initial doses should be increased until the desired effect is obtained or the side effects from blockade become troublesome. . The dosage should be carried to a point where symptomatic relief and/or objective improvement are obtained, but not so high that the side effects from blockade become troublesome.
  • Initially, 10 mg of phenoxybenzamine hydrochloride twice a day. Dosage should be increased every other day, usually to 20 to 40 mg 2 or 3 times a day, until an optimal dosage is obtained, as judged by blood pressure control.
  • Long-term use of phenoxybenzamine is not recommended (see : ).u00a0
  • Phenoxybenzamine Hydrochloride Capsules USP
  • 10 mg capsules is supplied as a red opaque/red opaque capsule with u201c54 036u201d printed in black on the cap and u201c54 036u201d printed in black ink on the capsule body, containing a white to off-white powder.
  • NDC 0054-0349-25: Bottle of 100 Capsules
  • Store at 20u00b0 to 25u00b0C (68u00b0 to 77u00b0F). [See USP Controlled Room Temperature.]
  • 10006462/03
  • Array
  • Revised May 2016
  • No data

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