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Silver Sulfadiazine (Silver Sulfadiazine)

Trade Name : Silver Sulfadiazine

NuCare Pharmaceuticals,Inc.

CREAM

Strength 10 mg/g

SILVER SULFADIAZINE Sulfonamide Antibacterial [EPC],Sulfonamides [CS]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Silver Sulfadiazine (Silver Sulfadiazine) which is also known as Silver Sulfadiazine and Manufactured by NuCare Pharmaceuticals,Inc.. It is available in strength of 10 mg/g per ml. Read more

Silver Sulfadiazine (Silver Sulfadiazine) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • Silver sulfadiazine cream, USP 1% is a soft, white, water dispersible cream containing the antimicrobial agent silver sulfadiazine in micronized form for topical application.u00a0 Each gram of silver sulfadiazine cream contains 10mg of micronized silver sulfadiazine.n n n u00a0u00a0 u00a0 This active agent has the following structural formula:n nn
  • Silver sulfadiazine cream contains 1% w/w silver sulfadiazine.u00a0 The vehicle in which the active ingredient is dispersed consists of water, stearyl alcohol, white petrolatum, polyoxyl 40 stearate, propylene glycol, isopropyl myristate, and sorbitan monooleate with 0.3% methylparaben as a preservative.
  • Silver sulfadiazine has broad antimicrobial activity. It is bactericidal for many gram-negative and gram-positive bacteria as well as being effective against yeast. Results from n n n testing are listed below.n n n u00a0u00a0 u00a0 Sufficient data have been obtained to demonstrate that silver sulfadiazine will inhibit bacteria that are resistant to other antimicrobial agents and that the compound is superior to sulfadiazine.n n n u00a0u00a0 u00a0 Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect.n nn
  • Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.
  • Silver sulfadiazine cream, USP 1% is a topical antimicrobial drug indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second and third degree burns.
  • Silver sulfadiazine cream, USP 1% is contraindicated in patients who are hypersensitive to silver sulfadiazine or any of the other ingredients in the preparation.n n n u00a0u00a0 u00a0 Because sulfonamide therapy is known to increase thenpossibility of kernicterus, silver sulfadiazine cream, USP 1% should not be used on pregnant women approaching or at term, on premature infants, or on newborn infants during the first 2 months of life.n nn
  • Absorption of silver sulfadiazine varies depending upon thenpercent of body surface area and the extent of the tissue damage. Although few have been reported, it is possible that any adverse reaction associated with sulfonamides may occur. Some of the reactions which have been associated with sulfonamides are as follows: blood dyscrasias including agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, and hemolytic anemia; dermatologic and allergic reactions, including life-threatening cutaneous reactions [Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and exfoliative dermatitis]; gastrointestinal reactions, hepatitis and hepatocellular necrosis; CNS reactions; and toxic nephrosis.n n n u00a0u00a0 u00a0 There is a potential cross-sensitivity between silver sulfadiazine and other sulfonamides.u00a0 If allergic reactions attributable to treatment with silver sulfadiazine occur, continuation of therapy must be weighed against the potential hazards of the particular allergic reaction.u00a0u00a0n n n u00a0u00a0 u00a0 Fungal proliferation in and below the eschar may occur.u00a0 However, the incidence of clinically reported fungal superinfection is low.n n n u00a0u00a0 u00a0 The use of silver sulfadiazine cream, USP 1% in some cases of glucose-6-phosphate dehydrogenase-deficient individuals may be hazardous, as hemolysis may occur.n nn
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  • Carcinogenesis, Mutagenesis, Impairment of Fertility.
  • Pregnancy Category B.
  • CONTRAINDICATIONS
  • Nursing Mothers.
  • Geriatric Use.
  • Pediatric Use.
  • CONTRAINDICATIONS
  • Several cases of transient leukopenia have been reported in patients receiving silver sulfadiazine therapy.n n n Leukopenia associated with silver sulfadiazine administration is primarily characterized by decreased neutrophil count.u00a0 Maximal white blood cell depression occurs within two to four days of initiation of therapy.u00a0 Rebound to normal leukocyte levels follows onset within two to three days.u00a0 Recovery is not influenced by continuation of silver sulfadiazine therapy. An increased incidence has been seen in patients treated concurrently with cimetidine.n n n u00a0u00a0 u00a0 Other infrequently occurring events include skin necrosis, erythema multiforme, skin discoloration, burning sensation, rashes, and interstitial nephritis.n n n u00a0u00a0 u00a0 Reduction in bacterial growth after application of topical antibacterial agents has been reported to permit spontaneous healing of deep partial-thickness burns by preventing conversion of the partial thickness to full thickness by sepsis.u00a0 However, reduction in bacterial colonization has caused delayed separation, in some cases necessitating escharotomy in order to prevent contracture.n nn
  • Prompt institution of appropriate regimens for care of the burned patient is of prime importance and includes the control of shock and pain. The burn wounds are then cleansed and debrided, silver sulfadiazine cream, USP 1% is then applied under sterile conditions. The burn areas should be covered with silver sulfadiazine cream, USP 1% at all times. The cream should be applied once to twice daily to a thickness of approximately one sixteenth of an inch. Whenever necessary, the cream should be reapplied to any areas from which it has been removed by patient activity. Administration may be accomplished in minimal time because dressings are not required. However, if individual patient requirements make dressings necessary, they may be used.n n n u00a0u00a0 u00a0 Reapply immediately after hydrotherapy. Treatment with silver sulfadiazine cream, USP 1% should be continued until satisfactory healing has occurred or until the burn site is ready for grafting. The drug should not be withdrawn from the therapeutic regimen while there remains the possibility of infection except if a significant adverse reaction occurs.n nn
  • Store at room temperature. 15u00b0-30u00b0C (56u00b0-86u00b0F).
  • Manufactured for:n- Manufactured by:
  • Product information: 1-877-272-7901
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